MATING PATTERNS IN SEMINATURAL POPULATIONS OF MICE INFLUENCED BY MHC GENOTYPE
MATING PATTERNS IN SEMINATURAL POPULATIONS OF MICE INFLUENCED BY MHC GENOTYPE
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DOI：
10.1038/352619a0
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发表时间：
1991-08-15
期刊：
影响因子：
64.8
通讯作者：
WAKELAND, EK
中科院分区：
文献类型：
--
作者：
POTTS, WK;MANNING, CJ;WAKELAND, EK
由于主要组织相容性复合体（MHC）基因在免疫识别中的核心作用1-3，通常认为寄生虫驱动的选择保持了这些基因前所未有的遗传多样性4-7。 但是，MHC基因型和特定传染病之间的关联很难确定8，9，只有少数例外，如马立克氏病10和疟疾11。或者，MHC相关的生殖机制，如选择性流产12-15和交配偏好16，17可能是造成多样性的原因。为了确定选择作用于MHC基因的性质和强度，我们研究了自然种群中小鼠（Mus musculus arteriticus）的选择成分。在这里，我们评估MHC相关的模式的繁殖和早期（断奶前）死亡率分析1,139个后代出生在9个人口，和662个后代从实验室交配。生殖机制，主要是交配偏好，导致MHC纯合子后代比随机交配预期少27%。MHC基因型对新生儿（断奶前）死亡率无明显影响。这些交配偏好是强大到足以占大多数的MHC遗传多样性在自然种群的Muss。
BECAUSE of the central role of major histocompatibility complex (MHC) genes in immune recognition 1-3, it is often assumed that parasite-driven selection maintains the unprecedented genetic diversity of these genes 4-7. But associations between MHC genotype and specific infectious diseases have been difficult to identify 8,9 with a few exceptions such as Marek's disease 10 and malaria 11. Alternatively, MHC-related reproductive mechanisms such as selective abortion 12-15 and mating preferences 16,17 could be responsible for the diversity. To determine both the nature and strength of selection operating on MHC genes by we have studied components of selection in seminatural populations of mice (Mus musculus domesticus). Here we assess MHC-related patterns of reproduction and early (preweaning) mortality by analysing 1,139 progeny born in nine populations, and 662 progeny from laboratory matings. Reproductive mechanisms, primarily mating preferences, result in 27% fewer MHC-homozygous offspring than expected from random mating. MHC genotype had no detectable influence on neonatal (preweaning) mortality. These mating preferences are strong enough to account for most of the MHC genetic diversity found in natural populations of Mus.