Short- and long-term animal studies with a plasma-sprayed calcium phosphate-coated implant
Short- and long-term animal studies with a plasma-sprayed calcium phosphate-coated implant
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DOI：
10.1034/j.1600-0501.1997.080501.x
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发表时间：
1997-10-01
影响因子：
4.3
通讯作者：
Albrektsson, T
中科院分区：
文献类型：
--
作者：
Gottlander, M;Johansson, CB;Albrektsson, T
在为期4周和24周的动物研究中，对市售羟基磷灰石（HA）涂层进行了研究。HA涂层和未涂层商业纯（c. p.）将钛螺纹植入物插入兔胫骨和股骨中。定性组织学显示两种类型植入物周围均存在巨细胞和巨噬细胞。组织形态测定表明，在两个随访阶段，与HA涂层样本接触的骨明显更多。相比之下，6个月随访后，骨面积测量（螺纹内部和/或外部的骨量）显示无涂层c. p.钛对照组周围的骨百分比显著更高。从长期来看，HA涂层种植体周围的骨量较少可能与巨噬细胞诱导的骨吸收有关。
A commercially available hydroxyapatite(HA)-coating was investigated in a 4- and 24-week animal study. HA-coated and uncoated commercially pure (c.p.) titanium threaded implants were inserted in rabbit tibia and femur. Qualitative histology showed giant cells and macrophages around both types of implants. Histomorphometry demonstrated significantly more bone in contact to the HA-coated specimens at both follow-up periods. In contrast, bone area measurements (the amount of bone inside and/or outside the threads) revealed significantly higher percentages of bone around the uncoated c.p. titanium controls after 6 months of follow-up. The inferior amount of bone around the HA-coated implants in the longer-term perspective may relate to macrophage-induced resorption.