Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1
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DOI：
10.1126/science.286.5444.1571
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发表时间：
1999-11-19
期刊：
影响因子：
56.9
通讯作者：
Fraser, CM
中科院分区：
文献类型：
--
作者：
White, O;Eisen, JA;Fraser, CM
耐辐射细菌耐辐射奇球菌R1的完整基因组序列由两条染色体（2,648,638和412,348个碱基对）、一个大质粒（172,466个碱基对）和一个小质粒（45,704个碱基对）组成，总基因组为3,284,156个碱基对。分布在染色体和巨质粒上的多种成分被确定，这些成分有助于耐辐射球菌在饥饿、氧化应激和大量 DNA 损伤的条件下生存。耐辐射奇球菌代表一种生物体，其中 DNA 修复、DNA 损伤输出、干燥和饥饿恢复以及遗传冗余的所有系统都存在于一个细胞中。
The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (172,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.