TERT gene: its function and dysregulation in cancer
TERT gene: its function and dysregulation in cancer
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DOI：
10.1136/jclinpath-2018-205653
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发表时间：
2019-04-01
影响因子：
3.4
通讯作者：
Cooper, Wendy A.
中科院分区：
文献类型：
--
作者：
Colebatch, Andrew J.;Dobrovic, Alexander;Cooper, Wendy A.
本文就端粒酶逆转录酶（TERT）的结构、功能及其调控进行综述。通过在一系列癌症的端粒酶启动子突变的失调进行了讨论。的分子机制激活的TERT启动子突变进行了概述。最后，在癌发生过程中的端粒酶启动子突变的时间审查的背景下，其潜在的效用作为恶性转化的临床生物标志物。
In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.