Reference intervals of complete blood count constituents are highly correlated to waist circumference: Should obese patients have their own "normal values?"
Reference intervals of complete blood count constituents are highly correlated to waist circumference: Should obese patients have their own "normal values?"
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DOI：
10.1002/ajh.23713
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发表时间：
2014-07-01
影响因子：
12.8
通讯作者：
Cembrowski, George
中科院分区：
文献类型：
--
作者：
Vuong, Jennifer;Qiu, Yuelin;Cembrowski, George
身体质量指数（BMI），肥胖的流行指标，是不容易掌握的病人和医生。腰围（WC）与肥胖相关，更好地理解，并与代谢综合征有更强的关系。我们收集了2005-2010年美国国家健康和营养调查中6766名25-55岁美国志愿者的WC、全血细胞计数（CBC）参数以及其他相关数据。为了确定典型的美国患者访问他们的临床医生的参考区间，我们使用最小排除标准。我们编制了血红蛋白、红细胞计数、红细胞压积、平均红细胞体积（MCV）、平均红细胞血红蛋白浓度、平均细胞血红蛋白（MCH）、红细胞分布宽度（RDW）、血小板计数、平均血小板体积以及白色细胞（WBC）、中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞计数。此外，我们还编制了血清C反应蛋白和血清铁。研究了美国的三个主要人种，并为每个CBC参数绘制了参考区间图。WBC计数、RDW、淋巴细胞、中性粒细胞和红细胞计数随WC增加。血清铁、MCH和MCV降低。这些关系可能与胰岛素抵抗和免疫系统的慢性激活以及由此产生的低度炎症状态有关。WC是许多CBC参数的强预测因子，这表明在评估血细胞计数结果时应考虑WC。照顾肥胖患者的临床医生应该注意血液学的改变，并进行相应的调查和治疗。(C)2014年威利期刊公司
Body mass index (BMI), the prevalent indicator of obesity, is not easily grasped by patients nor physicians. Waist circumference (WC) is correlated to obesity, is better understood and has a stronger relationship to the metabolic syndrome. We compiled WC, complete blood count (CBC) parameters as well as other pertinent data of 6766 25-55-year-old US volunteers sampled in the US National Health and Nutrition Examination Survey, in the years 2005-2010. To determine reference intervals of typical US patients visiting their clinician, we used minimal exclusion criteria. We compiled hemoglobin, red blood cell count, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration, mean cell hemoglobin (MCH), red cell distribution width (RDW), platelet count, mean platelet volume, and counts of white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, and basophils. In addition, we also compiled serum C reactive protein and serum iron. The three major US races were studied and reference interval diagrams were constructed for each CBC parameter plotted against WC. WBC count, RDW, lymphocyte, neutrophil, and red blood cell count increase with WC. Conversely, serum iron and MCH and MCV decrease. These relationships may be related to insulin resistance and chronic activation of the immune system and the resulting low-grade inflammatory state. WC is a strong predictor for many CBC parameters, suggesting that WC should be taken into account when evaluating blood count results. Clinicians who take care of obese patients should be aware of altered hematology and investigate and treat accordingly. (C) 2014 Wiley Periodicals, Inc.