Serum Cystatin C Levels in Renal Transplant Recipients
Serum Cystatin C Levels in Renal Transplant Recipients
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DOI：
10.1007/s12291-010-0084-0
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发表时间：
2011-04-01
影响因子：
2.1
通讯作者：
Venu, G.
中科院分区：
文献类型：
--
作者：
Krishnamurthy, N.;Arumugasamy, K.;Venu, G.
胱抑素 C 是评估肾同种异体移植功能的新兴参数。该研究的目的是比较血清胱抑素 C (SCys) 与既定参数血清肌酐 (SCr) 在肾移植受者 (RTR) 肾功能评估中的功效。采用Tc-99m二乙烯三胺五乙酸酯(DTPA)法测定30名肾移植患者和29名对照受试者的肾小球滤过率(GFR)。使用自动化 Jaffe 测定法测量 SCr，使用乳胶颗粒增强比浊免疫测定法 (PETIA) 测量 SCys。肾病饮食改良 (MDRD) 公式用于根据 SCr 计算 GFR，而 Le Bricon 公式用于根据 SCys 计算 GFR。使用MedCalc软件进行统计分析。与对照组相比，RTR 中 SCr 和 SCys 水平显着升高，而 DTPA 清除率显着降低 (P\0.0001)。根据MDRD法计算的GFR与DTPA清除率的相关系数（r值）为0.343（P = 0.06），而根据Le Bricon公式计算的GFR为0.694（P\0.001）。结果表明，在 RTR 中评估肾功能时，SCys 是比 SCr 更好的参数。将 SCys 作为附加参数肯定有助于检测肾功能的轻微下降，并有助于调整免疫抑制药物的剂量。
Cystatin C is an emerging parameter for the assessment of renal allograft function. The objective of the study was to compare the efficacy of serum cystatin C (SCys) with the established parameter serum creatinine (SCr) in the assessment of renal function in renal transplant recipients (RTR). The glomerular filtration rate (GFR) of 30 renal transplant patients and 29 control subjects was determined using Tc-99m Diethylene-triamine-penta-acetate (DTPA) method. SCr was measured using an automated Jaffe's assay and SCys was measured using latex particle enhanced turbidimetric immuno assay (PETIA). The modification of diet in renal disease (MDRD) formula was used to calculate GFR from SCr, while the Le Bricon formula was used to derive GFR based on SCys. Statistical analysis was performed using MedCalc software. SCr and SCys levels were significantly higher, while DTPA clearance was significantly lower in RTR (P\0.0001) when compared with controls. The correlation coefficient (r value) between calculated GFR based on MDRD method and DTPA clearance was 0.343 (P = 0.06) while the calculated GFR based on Le Bricon formula was 0.694 (P\0.001). The results have shown that SCys is a better parameter than SCr in assessing renal function in RTR. The inclusion of SCys as an additional parameter would certainly help in detection of even a marginal decline in renal function and also in adjusting the dosage of immunosuppressive drugs.