Friendly Fat Theory - Explaining the Paradox of Diabetes and Obesity.
Friendly Fat Theory - Explaining the Paradox of Diabetes and Obesity.
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DOI：
10.17925/ee.2019.15.1.25
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发表时间：
2019-04-01
影响因子：
--
通讯作者：
Gupta, Yashdeep
中科院分区：
文献类型：
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作者：
Singla, Rajiv;Murthy, Mithun;Gupta, Yashdeep
肥胖被称为所有疾病之母，并且在历史上与糖尿病密切相关。然而，在糖尿病流行病学和肥胖方面仍然存在一些悖论，并且没有提出统一的假说来解释这些悖论现象。尽管肥胖症和糖尿病的患病率不断增加，但在不同种族群体中，糖尿病与肥胖程度之间存在差异。此外，具有较高体重指数的人已被证明在慢性糖尿病并发症，特别是心血管并发症方面具有改善的生存优势。本文试图用一个统一的理论来解释这些矛盾而复杂的关系。我们认为脂肪细胞实际上是人体的朋友，可以预防糖尿病的发生，也有助于减轻糖尿病的并发症。脂肪组织实际上是游离脂肪酸的储存库，负责胰岛素抵抗，并防止它们溢出到胰岛素敏感组织，因此，友好的脂肪理论。
Obesity has been called the mother of all diseases and, historically, has been strongly linked to diabetes. However, there are still some paradoxes that exist in diabetes epidemiology and obesity and no unifying hypothesis has been proposed to explain these paradoxical phenomena. Despite the ever-increasing prevalence of both obesity and diabetes, differential relationships exist between diabetes and the extent of obesity in various different ethnic groups. In addition, people with a higher body mass index have been shown to have an improved survival advantage in terms of chronic diabetes complications, especially cardiovascular complications. This narrative review attempts to explain these paradoxical and complex relationships with a single unifying theory. We propose that adipocytes are actually friends of the human body to prevent the occurrence of diabetes and also help in mitigating the complications of diabetes. Adipose tissue actually acts as a reservoir of free fatty acids, responsible for insulin resistance, and prevents their overflow into insulin-sensitive tissues and, therefore, friendly fat theory.