Calcium dynamics and signaling in vascular regulation: computational models.
Calcium dynamics and signaling in vascular regulation: computational models.
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血管调节中的钙动力学和信号传导：计算模型。
DOI：
10.1002/wsbm.97
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Tsoukias,NikolaosMichael
中科院分区：
文献类型：
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作者：
Tsoukias,NikolaosMichael
钙是一种通用的信号分子，在许多血管功能中起核心作用，包括调节张力和血流。实验提供了深入了解导致或影响血管系统中Ca 2+动员的信号通路。数学建模提供了一个系统的方法来分析这些机制，并可以作为一种工具，数据解释和指导新的实验研究。钙动力学的综合模型对于某些系统（如心脏）来说是非常先进的。本文综述了近年来在血管细胞内钙动力学和信号传导模型方面的研究进展。模型模拟显示了Ca 2+信号是如何作为复杂的非线性相互作用的结果出现的，这些相互作用不能仅使用还原论的方法进行正确分析。概述了在脉管系统中的综合建模的策略，这将允许将宏观病理生理反应与潜在的细胞机制联系起来。WIRES Syst Biol Med 2011 3 93-106 DOI：10.1002/wsbm.97本文分类为：系统属性和过程模型>细胞模型生物机制>细胞信号传导
Calcium is a universal signaling molecule with a central role in a number of vascular functions including in the regulation of tone and blood flow. Experimentation has provided insights into signaling pathways that lead to or affected by Ca2+mobilization in the vasculature. Mathematical modeling offers a systematic approach to the analysis of these mechanisms and can serve as a tool for data interpretation and for guiding new experimental studies. Comprehensive models of calcium dynamics are well advanced for some systems such as the heart. This review summarizes the progress that has been made in modeling Ca2+dynamics and signaling in vascular cells. Model simulations show how Ca2+signaling emerges as a result of complex, nonlinear interactions that cannot be properly analyzed using only a reductionist's approach. A strategy of integrative modeling in the vasculature is outlined that will allow linking macroscale pathophysiological responses to the underlying cellular mechanisms.WIREs Syst Biol Med2011 3 93–106 DOI: 10.1002/wsbm.97This article is categorized under:Models of Systems Properties and Processes > Cellular ModelsBiological Mechanisms > Cell Signaling