Nephrogenic systemic fibrosis: A population study examining the relationship of disease development to gadolinium exposure
Nephrogenic systemic fibrosis: A population study examining the relationship of disease development to gadolinium exposure
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DOI：
10.2215/cjn.03921106
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发表时间：
2007-03-01
影响因子：
9.8
通讯作者：
Cowper, Shawn E.
中科院分区：
文献类型：
--
作者：
Deo, Aneet;Fogel, Mitchell;Cowper, Shawn E.
肾源性系统性纤维化（NSF）是严重肾衰竭的毁灭性并发症。最近的报告表明，暴露于含钆造影剂（GCCA）与NSF的发生有关。在18个月的时间内，对CT布里奇波特及其周围的ESRD患者人群进行了研究。NSF的发生率为4.3例/1000患者-年。每项使用钆的放射学研究显示NSF的风险为2.4%。钆暴露与NSF之间的相关性非常显著（P
Nephrogenic systemic fibrosis (NSF) is a devastating complication of severe renal failure. Recent reports suggest that exposure to gadolinium-containing contrast agents (GCCA) is associated with the occurrence of NSF. The population of patients with ESRD in and around Bridgeport, CT, was studied during an 18-mo period. The incidence of NSF was 4.3 cases per 1000 patient-years. Each radiologic study using gadolinium presented a 2.4% risk for NSF. The association between gadolinium exposure and NSF was highly significant (P