Risk of cancer, following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe
Risk of cancer, following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe
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DOI：
10.1016/j.ejca.2007.07.015
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发表时间：
2007-09-01
影响因子：
8.4
通讯作者：
Franceschi, Silvia
中科院分区：
文献类型：
--
作者：
Serraino, Diego;Piselli, Pierluca;Franceschi, Silvia
这项调查强调了意大利和法国8074名艾滋病毒感染者和2875名移植受者的癌症风险。通过性别和年龄标准化的发病率比（SIR）和95%置信区间（CI）比较观察到的和预期的癌症数量。经过15年的随访，移植受者的累积癌症概率为14.7%，HIV阳性者为13.3%。所有癌症的SIR在HIV阳性者中为9.8，在移植者中为2.2。卡波西肉瘤（HIV阳性SIR = 451，移植物SIR = 125）和非霍奇金淋巴瘤（SIR= 62和11.1，分别）是最常见的癌症。两组中肝癌的SIR也显著增加。心脏移植受者的肺癌风险显著升高（SIR = 2.8），HIV阳性者的肺癌风险具有边缘统计学意义（95%CI：0.92.8）。免疫抑制导致癌症的总体风险增加两倍，主要与病毒病因相关的癌症有关。(C)2007爱思唯尔有限公司保留所有权利。
This investigation highlighted the risk of cancer in 8074 HIV-infected people and in 2875 transplant recipients in Italy and France. Observed and expected numbers of cancer were compared through sex- and age-standardised incidence ratios (SIRs) and 95% confidence intervals (CIs). After 15 years of follow-up, the cumulative probability of cancer was 14.7% in transplant recipients and 13.3% in HIV-positives. The SIRs for all cancers were 9.8 in HIV-positives and 2.2 in transplants. Kaposi's sarcoma (SIR = 451 in HIV-positives, 125 in transplants) and non-Hodgkin lymphoma (SIR= 62 and 11.1, respectively) were the most common cancers. A significantly increased SIR for liver cancer also emerged in both groups. The risk of lung cancer was significantly elevated in heart transplant recipients (SIR = 2.8), and of borderline statistical significance in HIV-positive people (95% CI:0.92.8). Immune depression entails a two-fold increased overall risk of cancers, mainly related to cancers associated with a viral aetiology. (C) 2007 Elsevier Ltd. All rights reserved.