Hepatosplanchnic clearance of interleukin-6 in humans during exercise
Hepatosplanchnic clearance of interleukin-6 in humans during exercise
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DOI：
10.1152/ajpendo.00134.2003
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发表时间：
2003-08-01
影响因子：
5.1
通讯作者：
Pedersen, BK
中科院分区：
文献类型：
--
作者：
Febbraio, MA;Ott, P;Pedersen, BK
细胞因子白细胞介素（IL）-6可以在运动过程中显著增加，但肝脏是否是这种增加的来源尚不清楚。本研究的目的是测量IL-6通过人类肝组织的通量。为了提高全身浓度的IL-6，6名健康男性受试者进行120分钟的半卧位骑自行车，和血液样本同时获得肱动脉和肝静脉前和运动过程中的IL-6的分析。采用吲哚菁绿色灌注技术测定肝血流量。根据这些测量值计算肝组织IL-6净平衡。静息时HBF为1.3 +/- 0.1 l/min，运动过程中HBF未降低，平均为1.1 +/- 0.2 l/min。动脉血浆IL-6从静息时的1.8 +/- 0.6 ng/l显著升高（P < 0.05），运动120 min后升高至14.3 +/- 3.2 ng/l。肝内脏对这种增加没有贡献，因为存在肝内脏IL-6净摄取（0.8 +/- 0.3 vs. 5.5 +/- 1.9 ng/min，休息vs. 120 min; P < 0.05）。这些数据表明，hepatosplanchnic内脏从人体循环中去除IL-6。这种去除可能构成限制慢性升高的循环IL-6的负性慢性代谢作用的机制。
The cytokine interleukin (IL)-6 can increase markedly in the circulation during exercise, but whether the liver is a source of this increase is unknown. The aim of this study was to measure IL-6 flux across the hepatosplanchnic tissues in humans. To elevate systemic concentrations of IL-6, six healthy male subjects performed 120 min of semirecumbent cycling, and blood samples were simultaneously obtained from a brachial artery and the hepatic vein before and during exercise for the analysis of IL-6. Hepatosplanchnic blood flow ( HBF) was measured using the indocyanine green infusion technique. Net hepatosplanchnic IL-6 balance was calculated from these measures. HBF was 1.3 +/- 0.1 l/min at rest and was not reduced throughout exercise, averaging 1.1 +/- 0.2 l/min. Arterial plasma IL-6 markedly increased ( P < 0.05) from 1.8 +/- 0.6 ng/l at rest to 14.3 +/- 3.2 ng/l after 120 min of exercise. The hepatosplanchnic viscera did not contribute to this increase, since there was a net hepatosplanchnic IL-6 uptake ( 0.8 +/- 0.3 vs. 5.5 +/- 1.9 ng/min, rest vs. 120 min; P < 0.05). These data demonstrate that the hepatosplanchnic viscera remove IL-6 from the circulation in humans. This removal may constitute a mechanism limiting the negative chronic metabolic action of chronically elevated circulating IL-6.