Application of Optical Coherence Tomography in the Detection and Classification of Cognitive Decline.
Application of Optical Coherence Tomography in the Detection and Classification of Cognitive Decline.
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DOI：
10.5005/jp-journals-10028-1238
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发表时间：
2018-01
影响因子：
--
通讯作者：
Ramulu PY
中科院分区：
文献类型：
--
作者：
Lee MJ;Abraham AG;Swenor BK;Sharrett AR;Ramulu PY
本文旨在批判性地分析当前关于光学相干断层扫描（OCT）测量与认知和痴呆之间关系的文献。光学相干断层扫描（一种无创的神经视网膜层成像方法）和OCT血管造影（一种高度精确的视网膜血管检查方法）已被广泛用于帮助诊断和监测各种眼部疾病。现在有越来越多的证据表明视网膜的结构和微血管变化与认知障碍有关。总的来说，一些研究发现阿尔茨海默病（AD）和轻度认知障碍（MCI）的视网膜神经纤维层（RNFL）厚度减少，RNFL厚度与认知能力的持续测量之间存在关联，尽管研究结果不一致。在许多研究中，发现RNFL的特定区域存在关联，但与整体厚度无关。目前还缺乏将OCT测量与非阿尔茨海默氏痴呆症联系起来的研究，并且对过去认知能力下降但仍保持认知正常（目标治疗的理想阶段）的人进行了有限的研究。以往研究的常见局限性包括未能考虑眼内压（IOP）和眼轴长度。目前的研究表明，在OCT上观察到的视网膜发现与认知障碍之间存在潜在的关联。为了更好地描述OCT和认知能力之间的关系，需要在方法上进行强有力的研究，考虑重要的协变量，并观察OCT和/或认知的变化。需要进一步的研究来确定OCT的发现是否有助于识别认知能力下降的病因和/或作为AD的客观标志物。如果是这种情况，OCT也可以帮助识别认知正常个体的疾病过程。本文摘自：Lee MJ， Abraham AG, Swenor BK, Sharrett AR, Ramulu PY。光学相干层析成像在认知衰退检测与分类中的应用。中国当代青光眼杂志，2018;12(1):10-18。
This review aims to critically analyze the current literature on the relationship of optical coherence tomography (OCT) measures to cognition and dementia. Optical coherence tomography, a noninvasive method of imaging neuroretinal layers, and OCT angiography, a highly precise method of examining retinal vasculature, have widely been used to aid in the diagnosis and monitoring of a variety of ocular diseases. There is now an increasing body of evidence relating the structural and microvascular changes of the retina to cognitive impairment. In general, several studies have found decreased retinal nerve fiber layer (RNFL) thickness in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and an association between RNFL thickness and continuous measures of cognitive ability, though findings were inconsistent across studies. In many studies, associations were found for specific regions of the RNFL but not with overall thickness. Studies linking OCT measures to non-Alzheimer’s dementia were lacking, and limited work has been done on persons with past cognitive decline but who remain cognitively normal (the ideal stage at which to target treatment). Common limitations of prior studies include a failure to account for intraocular pressure (IOP) and axial length. Current research suggests a potential association between retinal findings observed on OCT and cognitive impairment. Methodologically robust research accounting for important covariates and looking at changes in OCT and/ or cognition is needed to better characterize the association between OCT and cognitive ability. Further research is warranted to determine whether OCT findings can help identify the etiology of cognitive decline and/or serve as objective markers of AD. If this is the case, OCT may also help identify the presence of disease processes in cognitively normal individuals. How to cite this article: Lee MJ, Abraham AG, Swenor BK, Sharrett AR, Ramulu PY. Application of Optical Coherence Tomography in the Detection and Classification of Cognitive Decline. J Curr Glaucoma Pract 2018;12(1):10-18.