MMP-7 overexpression is an independent prognostic marker in gastric cancer
MMP-7 overexpression is an independent prognostic marker in gastric cancer
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DOI：
10.1007/s13277-010-0020-1
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发表时间：
2010-06-01
期刊：
影响因子：
--
通讯作者：
Haglund, Caj
中科院分区：
文献类型：
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作者：
Koskensalo, Selja;Mrena, Johanna;Haglund, Caj
为了使癌症能够侵入并转移，周围的基质必须被降解。基质金属蛋白酶-7 (MMP-7) 能够降解许多细胞外基质蛋白和细胞粘附，在许多恶性肿瘤中过度表达，并在肿瘤进展中发挥作用。本研究的目的是评估MMP-7组织表达与胃癌患者预后之间的关系。从 264 名接受胃癌手术的患者中，将手术标本收集到组织阵列块上，并通过免疫组织化学对 MMP-7 进行染色。在 27 个样本（10.2%）中，免疫阳性结果为高，50 个样本（18.9%）为中度，51 个样本（19.3%）为弱。 136例（51.5%）免疫阳性呈阴性。 MMP-7 高表达与生存率低之间存在统计学上显着的相关性。总之，我们的结果表明 MMP-7 表达可能有助于评估胃癌预后。
To enable cancer to invade and to metastasize, the surrounding stroma must be degraded. Matrix metalloproteinase-7 (MMP-7) is capable of degrading many extracellular matrix proteins and cellular adhesions, is overexpressed in many malignancies, and plays a role in tumour progression. The purpose of this study was to evaluate the association between MMP-7 tissue expression and patients' prognosis in gastric cancer. From 264 patients who underwent surgery for gastric cancer, surgical specimens were collected on tissue array blocks and stained by immunohistochemistry for MMP-7. In 27 (10.2%) of the specimens, immunopositivity was found as high, in 50 (18.9%) as moderate and in 51 (19.3%) as weak. In 136 cases (51.5%), the immunopositivity was negative. A statistically significant correlation appeared between high MMP-7 expression and poor survival. In conclusion, our results suggest that MMP-7 expression may prove helpful in evaluating gastric cancer prognosis.