Information about movement direction obtained from synchronous activity of motor cortical neurons
Information about movement direction obtained from synchronous activity of motor cortical neurons
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DOI：
10.1073/pnas.95.26.15706
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发表时间：
1998-12-22
影响因子：
11.1
通讯作者：
Donoghue, JP
中科院分区：
文献类型：
--
作者：
Hatsopoulos, NG;Ojakangas, CL;Donoghue, JP
虽然已证实初级运动皮质(MI)存在神经元同步化，但对其对运动编码的可能贡献却知之甚少。通过使用MI中多个神经元记录的互相关技术，我们观察到神经元的活动通常在运动开始时间附近同步。对于一些细胞对，同步性随方向变化，而这种变化方式并不容易被任何一个神经元的放电所预测。信息论分析定量地证明，同步性提供了关于运动方向的信息，而不是简单的速率变化所预期的信息。因此，MI神经元不仅是运动参数的独立编码者，而且还参与相互作用，这可能潜在地在皮质中提供额外的编码维度。
Although neuronal synchronization has been shown to exist in primary motor cortex (MI), very little is known about its possible contribution to coding of movement. By using cross-correlation techniques from multi-neuron recordings in MI, we observed that activity of neurons commonly synchronized around the time of movement initiation. For some cell pairs, synchrony varied with direction in a manner not readily predicted by the firing of either neuron. Information theoretic analysis demonstrated quantitatively that synchrony provides information about movement direction beyond that expected by simple rate changes. Thus, MI neurons are not simply independent encoders of movement parameters but rather engage in mutual interactions that could potentially provide an additional coding dimension in cortex.