A Laboratory-Based Surveillance System for Wuchereria bancrofti in Togo: A Practical Model for Resource-Poor Settings
A Laboratory-Based Surveillance System for Wuchereria bancrofti in Togo: A Practical Model for Resource-Poor Settings
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DOI：
10.4269/ajtmh.2011.10-0610
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发表时间：
2011-06-01
影响因子：
3.3
通讯作者：
Sodahlon, Yao K.
中科院分区：
文献类型：
--
作者：
Mathieu, Els;Dorkenoo, Ameyo;Sodahlon, Yao K.
消除淋巴丝虫病全球规划（GAELF）的目标之一是在淋巴丝虫病患病率大于1%的地区，通过每年大规模给药（MDA）阻断疾病传播。在MDAs完成后，世界卫生组织（世卫组织）建议在实现消灭LF的最终认证之前进行一段时间的被动监测。这种监测系统的准则尚未制定。本文介绍了2006年在多哥启动的一个监测系统。该系统利用现有的实验室，配备夜间随叫随到的技术人员，他们除其他活动外，准备用于疟疾诊断的夜间浓血涂片，该涂片也可用于LF诊断。在前两年（2006-2007年），该系统在全国范围内进行了地理上分散的抽样，对居住在多哥的750人中有1人进行了测试。在同一时期，该系统发现了两例LF病例，均来自以前被认为是非流行地区。这一系统可成为世卫组织在停止大剂量药物治疗后强制进行被动监测的一种成本效益高、可持续的模式。
One goal of the Global Program to Eliminate Lymphatic Filariasis (GAELF) is interruption of disease transmission through annual mass drug administration (MDA) in areas where LF prevalence is greater than 1%. After MDAs are completed, the World Health Organization (WHO) recommends a period of passive surveillance before final certification of LF elimination is achieved. Guidelines for such a surveillance system have yet to be developed. This paper describes a surveillance system launched in Togo in 2006. The system uses existing laboratories with technicians on call at night who, among other activities, prepare nocturnal thick blood smears for malaria diagnosis that can also be used for LF diagnosis. During its first 2 years (2006-2007), the system provided geographically disperse sampling nationwide, and 1 of 750 people residing in Togo was tested. Over the same period, the system detected two cases of LF, both from areas previously considered non-endemic. This system could be a cost-effective, sustainable model for WHO-mandated passive surveillance after cessation of MDA.