The maximum length for contraction in vertebrate striated muscle
The maximum length for contraction in vertebrate striated muscle
复制标题
脊椎动物横纹肌收缩的最大长度
DOI：
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发表时间：
1961
期刊：
影响因子：
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通讯作者：
L. D. PEACHEYt
中科院分区：
文献类型：
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作者：
B. A. Huxley;L. D. PEACHEYt
在他们著名的关于分离肌肉纤维的实验中，Ramsey&Street(1940)表明，在等长破伤风期间，当长度增加到接近静止长度的某个值11l以上时，张力上升线性下降，当纤维被拉伸到大约两倍于这个长度时，张力上升到零。A.F.Huxley和Niedergerke(1954)指出，如果假设两组肌丝之间的相对作用力是在两组肌丝重叠的区域中的若干位置产生的，则他们和H.E.Huxley&Hanson(1954)提出的肌肉收缩的滑丝理论对这一结果给出了简单的解释。如果这些部位均匀分布，产生的总张力应该与重叠区的长度成正比，重叠区的长度应该随着肌节长度从大约2-0，u(次生丝的长度)增加而线性下降，在肌节长度约为3-5(初级肌节(约1-5)和次生丝的长度的总和)时达到零。然而，这一解释有几个不确定因素，如下所示。
In their well-known experiments on isolated muscle fibres, Ramsey & Street (1940) showed that the rise of tension during an isometric tetanus decreases linearly as the length is increased beyond a certain value 1l near to the resting length, reaching zero when the fibre is stretched to about twice this length. A. F. Huxley & Niedergerke (1954) pointed out that a simple explanation for this result was given by the sliding-filament theory of muscular contraction put forward by them and by H. E. Huxley (1953; H. E. Huxley & Hanson, 1954), if it is supposed that a relative force between filaments of the two sets is generated at each of a number of sites in the zone where the two sets of filaments overlap. If these sites are distributed evenly, the total tension generated should be proportional to the length of the overlap zone, which should decrease linearly as the sarcomere length is increased from about 2-0 ,u (the length of the secondary filaments), reaching zero at a sarcomere length of about 3-5 , (the sum of the lengths of the primary (about 1-5 ,) and of the secondary filaments). There were, however, several uncertainties about this explanation, as follows.