Non-Coding RNAs in Hereditary Kidney Disorders.
Non-Coding RNAs in Hereditary Kidney Disorders.
复制标题
DOI：
10.3390/ijms22063014
复制
发表时间：
2021-03-16
影响因子：
5.6
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Zhou JX;Li X
随着分子遗传学的发展，单基因缺陷已被发现是许多肾脏疾病的病因。常染色体显性遗传性多囊肾病（autosomaldominantpolycystickiddisease，ADPKD）是由PKD 1或PKD 2基因突变引起的一种常见的遗传性肾脏病。由于囊肿形成和进展的病理生理学的复杂性，可用的治疗选择有限。近年来，非编码RNA在发育和疾病中的作用得到了广泛的关注。特别是，促进PKD进展的microRNA已被强调。这些失调的microRNA通过抑制PKD基因的表达、调节囊性肾上皮细胞增殖、线粒体代谢、凋亡和自噬来调节囊肿生长。microRNA拮抗剂已成为治疗ADPKD的潜在药物。此外，研究还关注microRNA作为ADPKD和其他常见遗传性肾病的潜在生物标志物，包括HNF 1 β相关肾病、Alport综合征、先天性肾脏和泌尿道异常（CAKUT）、von Hippel-Lindau（VHL）病和Fabry病。本文综述了目前对多囊肾和常见单基因肾病中非编码RNA的研究进展。
Single-gene defects have been revealed to be the etiologies of many kidney diseases with the recent advances in molecular genetics. Autosomal dominant polycystic kidney disease (ADPKD), as one of the most common inherited kidney diseases, is caused by mutations of PKD1 or PKD2 gene. Due to the complexity of pathophysiology of cyst formation and progression, limited therapeutic options are available. The roles of noncoding RNAs in development and disease have gained widespread attention in recent years. In particular, microRNAs in promoting PKD progression have been highlighted. The dysregulated microRNAs modulate cyst growth through suppressing the expression of PKD genes and regulating cystic renal epithelial cell proliferation, mitochondrial metabolism, apoptosis and autophagy. The antagonists of microRNAs have emerged as potential therapeutic drugs for the treatment of ADPKD. In addition, studies have also focused on microRNAs as potential biomarkers for ADPKD and other common hereditary kidney diseases, including HNF1β-associated kidney disease, Alport syndrome, congenital abnormalities of the kidney and urinary tract (CAKUT), von Hippel–Lindau (VHL) disease, and Fabry disease. This review assembles the current understanding of the non-coding RNAs, including microRNAs and long noncoding RNAs, in polycystic kidney disease and these common monogenic kidney diseases.
登录
查看更多内容
影响因子：
12.4
作者：
Brinkmann, Kerstin;Ng, Ashley P.;Herold, Marco J.
通讯作者：
Herold, Marco J.
影响因子：
2.3
作者：
Bartram MP;Dafinger C;Habbig S;Benzing T;Schermer B;Müller RU
通讯作者：
Müller RU
影响因子：
64.8
作者：
Denli, AM;Tops, BBJ;Hannon, GJ
通讯作者：
Hannon, GJ
DOI：
10.1016/j.matbio.2016.08.005
发表时间：
2017-01
期刊：
Matrix biology : journal of the International Society for Matrix Biology
影响因子：
--
作者：
Cosgrove D;Liu S
通讯作者：
Liu S
影响因子：
30.8
作者：
de Pontual, Loic;Yao, Evelyn;Callier, Patrick;Faivre, Laurence;Drouin, Valerie;Cariou, Sandra;Van Haeringen, Arie;Genevieve, David;Goldenberg, Alice;Oufadem, Myriam;Manouvrier, Sylvie;Munnich, Arnold;Vidigal, Joana Alves;Vekemans, Michel;Lyonnet, Stanislas;Henrion-Caude, Alexandra;Ventura, Andrea;Amiel, Jeanne
通讯作者：
Amiel, Jeanne