SLEEP WAKE CYCLE IN HUMAN AFRICAN TRYPANOSOMIASIS
SLEEP WAKE CYCLE IN HUMAN AFRICAN TRYPANOSOMIASIS
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DOI：
10.1097/00004691-199304000-00006
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发表时间：
1993-04-01
影响因子：
2.4
通讯作者：
DUMAS, M
中科院分区：
文献类型：
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作者：
BUGUET, A;BERT, J;DUMAS, M
昏睡病患者通常被描述为白天昏昏欲睡，晚上焦躁不安。在这项研究之前，我们通过记录一名非洲锥虫病患者的24小时睡眠模式，客观地证实了这一描述。我们报告了在脑膜脑炎早期未经治疗的昏睡病患者的两个八通道脑电图仪上进行的24小时多导睡眠图记录(脑电、眼电、肌电、心电图、鼻、颊和胸腔呼吸痕迹)。正如我们之前报告的患者一样，没有睡眠过多。患者主要表现为睡眠和清醒的昼夜交替的紊乱，在疾病的早期阶段，警觉状态没有或几乎没有改变。组织紊乱程度与临床症状严重程度成正比。这可能是由于生物钟机制的改变。
Sleeping sickness patients are classically described as sleepy by day and restless by night. Prior to this study, we had objectively confirmed this description by recording 24-h sleep patterns in a patient with human African trypanosomiasis. We report 24-h polysomnographic recordings (EEG, electrooculogram, electromyogram, electrocardiogram, and nasal, buccal, and thoracic respiratory traces) performed on two eight-channel electroencephalographs in eight patients with untreated sleeping sickness at an early stage of meningoencephalitis. As in our previously reported patient, there was no hypersomnia. The patients presented mainly a disorganization of the circadian alternation of sleeping and waking, with no or little alteration in the states of vigilance at this early stage of the disease. The disorganization was proportional to the degree of severity of the clinical symptoms. It may be due to an alteration in biological clock mechanisms.