Effects of 5-HT1A receptor agonists on hypothalamo-pituitary-adrenal axis activity and corticotropin-releasing factor containing neurons in the rat brain.
Effects of 5-HT1A receptor agonists on hypothalamo-pituitary-adrenal axis activity and corticotropin-releasing factor containing neurons in the rat brain.
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DOI：
10.1016/0014-2999(90)94118-h
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发表时间：
1990-11
影响因子：
5
通讯作者：
M. Owens;E. Edwards;C. Nemeroff
中科院分区：
文献类型：
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作者：
M. Owens;E. Edwards;C. Nemeroff
促肾上腺皮质激素释放因子（CRF）是下丘脑-垂体-肾上腺轴的主要生理调节因子。有证据表明，从下丘脑释放CRF是在刺激性肾上腺素能控制下。介导这种效应的特定5-HT受体亚型尚不清楚。对大鼠给予5-HT 1A激动剂8-OH-DPAT（1 mg/kg）和伊沙匹隆（4 mg/kg）导致HPA轴激活，这可通过急性治疗大鼠血浆ACTH和皮质酮浓度增加以及急性和慢性治疗大鼠血浆皮质酮浓度增加来证明。然而，这些化合物的长期给药未能改变中央隆起的CRF浓度或垂体前叶的CRF受体数量或亲和力。慢性给药的两种化合物导致CRF的浓度增加梨状皮质和海马，而8-OH-DPAT单独增加CRF的浓度在杏仁核和内嗅皮质。这些结果表明，下丘脑和下丘脑外CRF神经元均受5-HT_（1A）受体激活的影响。
Corticotropin-releasing factor (CRF) is the major physiological regulator of the hypothalamo-pituitary-adrenal axis. There is evidence that CRF release from the hypothalamus is under stimulatory serotonergic control. The specific 5-HT receptor subtypes that mediate this effect is unclear. Administration of the 5-HT1Aagonists, 8-OH-DPAT (1 mg/kg) and ipsapirone (4 mg/kg), to rats resulted in activation of the HPA axis as evidenced by increased plasma ACTH and corticosterone concentrations in acutely treated rats and increased plasma corticosterone concentrations in both acutely and chronically treated rats. However, chronic administration of these compounds failed to alter CRF concentrations in the median eminence or CRF receptor number or affinity in the anterior pituitary. Chronic administration of both compounds resulted in increased CRF concentrations in the piriform cortex and hippocampus, whereas 8-OH-DPAT alone increased CRF concentrations in the amygdala and entorhinal cortex. These results suggest that both hypothalamic and extrahypothalamic CRF neurons are influenced by activation of 5-HT1Areceptors.