Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients
Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients
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DOI：
10.1016/j.oraloncology.2008.08.011
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发表时间：
2009-07-01
期刊：
影响因子：
4.8
通讯作者：
Kuo, Mark Yen-Ping
中科院分区：
文献类型：
--
作者：
Chang, Hao-Hueng;Chiang, Chun-Pin;Kuo, Mark Yen-Ping
组蛋白脱乙酰酶2(HDAC2)与多种人类肿瘤的发生发展密切相关。应用免疫组织化学方法检测了20例口腔上皮异型增生(OED)和93例口腔鳞癌(OSCC)组织中HDAC2蛋白的表达。93例鳞癌中80例(86.02%)HDAC2阳性，20例ED中11例(55%)阳性。HDAC2核染色的标记指数(LI)从ED(25.8%+/-26.5%)增加到SCC(59.8%+/-28.5%)(p<；0.001)。口腔鳞癌患者HDAC2的表达水平与患者的年龄、性别、口腔习惯无关。而晚期、肿瘤体积较大或淋巴结转移阳性的癌组织中，HDAC2蛋白的表达水平较高。Kaplan-Meier曲线显示，HDAC2高表达(LI>；50%)、晚期、肿瘤体积较大或淋巴结转移阳性的口腔鳞癌患者的总生存期显著短于其他患者(经LOG检验，p分别为0.0158、0.0267、0.0029和0.02514)。本研究结果首次表明HDAC蛋白的过度表达是口腔鳞癌的常见事件，可作为口腔鳞癌的预后因素。(C)2008爱思唯尔有限公司。保留所有权利。
Histone deacetylase 2 (HDAC2) has been implicated in the development and progression of several human tumors. We immunohistochemically examined the expression of HDAC2 protein in 20 cases of oral epithelial dysplasia (OED) and 93 cases of oral squamous cell carcinoma (OSCC). Positive HDAC2 nuclear staining was observed in 80 of the 93 (86.02%) cases of SCC and 11 of the 20 (55%) cases of ED. The labeling index (LI) for HDAC2 nuclear staining increased significantly from ED (25.8 +/- 26.5%) to SCCs (59.8 +/- 28.5%) (p < 0.001). No significant correlation was found between the HDAC2 expression level and patient's age, sex, oral habits in oral SCC patients. However, cancer with advanced stage, larger tumor size, or positive lymph node metastasis had higher level of HDAC2 protein expression. Kaplan-Meier curves showed oral SCC patients with high HDAC2 expression (LI > 50%), advanced stage, larger tumor size, or positive lymph node metastasis had significantly shorter overall survival (p = 0.0158, 0.0267, 0.0029 and 0.02514, respectively by log-rank test) than others. The results of this study show for the first time that overexpression of the HDAC protein is a frequent event in oral cancer and could be used as a prognostic factor in oral SCC. (C) 2008 Elsevier Ltd. All rights reserved.