Dissociable Roles of Right Inferior Frontal Cortex and Anterior Insula in Inhibitory Control: Evidence from Intrinsic and Task-Related Functional Parcellation, Connectivity, and Response Profile Analyses across Multiple Datasets
Dissociable Roles of Right Inferior Frontal Cortex and Anterior Insula in Inhibitory Control: Evidence from Intrinsic and Task-Related Functional Parcellation, Connectivity, and Response Profile Analyses across Multiple Datasets
复制标题
DOI：
10.1523/jneurosci.3048-14.2014
复制
发表时间：
2014-10-29
影响因子：
5.3
通讯作者：
Menon, Vinod
中科院分区：
文献类型：
--
作者：
Cai, Weidong;Ryali, Srikanth;Menon, Vinod
右下额叶皮层（rIFC）和右前额叶皮层（rAI）一直与抑制控制有关，但它们的不同作用知之甚少。在这里，我们使用多种定量技术来分离的功能组织和作用的rAI和rIFC。我们首先对70项已发表的抑制性对照研究进行了荟萃分析，以生成一个常见的激活右额盖皮层感兴趣体积（VOI）。然后，我们使用两种类型的特征分割VOI：（1）内在脑活动;（2）停止信号任务诱发的血流动力学反应曲线。在这两种情况下，分割算法确定了两个稳定和不同的集群，包括rAI和rIFC。rAI和rIFC簇表现出几种不同的功能特征。首先，rAI表现出较强的内在和任务诱发的功能连接与前扣带皮层，而rIFC有较强的内在和任务诱发的功能连接与背内侧前额叶和外侧额顶叶皮层。第二，在不成功但不成功的停止试验期间，rAI显示出比rIFC更大的激活，并且rAI中的多体素反应特征，而不是rIFC，准确区分了成功和不成功的停止试验。第三，激活rIFC，而不是rAI，预测抑制控制能力的个体差异。至关重要的是，这些发现在两个独立的人类参与者队列中得到了复制。总之，我们的研究结果为rAI和rIFC在抑制控制中的可分离作用提供了新的定量证据。我们认为，rAI是特别重要的检测行为的显着事件，而rIFC是更多地参与实施抑制控制。
The right inferior frontal cortex (rIFC) and the right anterior insula (rAI) have been implicated consistently in inhibitory control, but their differential roles are poorly understood. Here we use multiple quantitative techniques to dissociate the functional organization and roles of the rAI and rIFC. We first conducted a meta-analysis of 70 published inhibitory control studies to generate a commonly activated right fronto-opercular cortex volume of interest (VOI). We then segmented this VOI using two types of features: (1) intrinsic brain activity; and (2) stop-signal task-evoked hemodynamic response profiles. In both cases, segmentation algorithms identified two stable and distinct clusters encompassing the rAI and rIFC. The rAI and rIFC clusters exhibited several distinct functional characteristics. First, the rAI showed stronger intrinsic and task-evoked functional connectivity with the anterior cingulate cortex, whereas the rIFC had stronger intrinsic and task-evoked functional connectivity with dorsomedial prefrontal and lateral fronto-parietal cortices. Second, the rAI showed greater activation than the rIFC during Unsuccessful, but not Successful, Stop trials, and multivoxel response profiles in the rAI, but not the rIFC, accurately differentiated between Successful and Unsuccessful Stop trials. Third, activation in the rIFC, but not rAI, predicted individual differences in inhibitory control abilities. Crucially, these findings were replicated in two independent cohorts of human participants. Together, our findings provide novel quantitative evidence for the dissociable roles of the rAI and rIFC in inhibitory control. We suggest that the rAI is particularly important for detecting behaviorally salient events, whereas the rIFC is more involved in implementing inhibitory control.