The varying patterns of neurotrophin changes in the perinatal period
The varying patterns of neurotrophin changes in the perinatal period
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DOI：
10.1196/annals.1365.041
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
Hassiakos, D.
中科院分区：
文献类型：
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作者：
Nikolaou, K. E.;Malamitsi-Puchner, A.;Hassiakos, D.
神经营养因子（NTs）、神经生长因子（NGF）、脑源性神经营养因子（BDNF）、NT-3和NT-4因其神经保护作用在产前和产后脑发育中起重要作用。发育变化改变了神经元对某些NTs的反应，这些NTs随后以不同的方式表达，以适当地平衡它们的作用。下面的研究旨在通过测定其在特征时间点的循环水平，研究30个适合胎龄（AGA）足月胎儿和新生儿的四种nt - ngf、BDNF、NT-3和NT-4的围产期变化模式。该研究显示，从脐带（UC）到新生儿第4天(M)， NTs、NT-3和NT-4的循环水平逐渐下降，而NGF和BDNF的循环水平呈现相反的模式：从脐带（UC）到新生儿第4天(M)增加。这些模式的围产期变化根据其对神经元发育过程的影响及其对围产期应激的反应而有所不同。已有文献记载，NT3和NT4在神经元发育的早期阶段起作用，在缺氧缺血后减少，而NGF和BDNF增加。进一步的研究应该在早产儿或足月婴儿中调查这些模式，在围产期出现各种病理状况。
Neurotrophins (NTs), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4 are of major importance in prenatal and postnatal brain development, due to their neuroprotective action. Developmental changes alter the neuronal responsiveness to certain NTs, which subsequently are variously expressed, to properly balance their action. The following study aimed at examining the pattern of perinatal changes of the four NTs-NGF, BDNF, NT-3, and NT-4 in 30 appropriate for gestational age (AGA) full-term fetuses and neonates by determining their circulating levels at characteristic time points. This study show a gradual decrease of circulating levels of the NTs, NT-3 and NT-4 from umbilical cord (UC) to neonates day 4 (M), while circulating levels of NGF and BDNF present the opposite pattern: an increase from UC to N4. These patterns of perinatal changes differ according to their impact on the process of neuronal development and their reaction to perinatal stress. NT3 and NT4 have been documented to act at early stages of neuronal development and to decrease after hypoxia-ischemia, while NGF and BDNF to increase. Further studies should investigate these patterns in premature or full-term infants, presenting various pathological conditions in the perinatal period.