High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes
High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes
复制标题
DOI：
10.2215/cjn.04271007
复制
发表时间：
2008-05-01
影响因子：
9.8
通讯作者：
Krolewski, Andrzej S.
中科院分区：
文献类型：
--
作者：
Rosolowsky, Elizabeth T.;Ficociello, Linda H.;Krolewski, Andrzej S.
背景和目的：1型糖尿病患者在蛋白尿发作前就开始出现早期肾功能下降。血清尿酸升高与晚期肾功能损害的关联提示其在蛋白尿development.Design，设置，参与者，和测量：1型糖尿病和normoalbuminuria或微量白蛋白尿患者的早期肾功能下降的作用的检查被招募到第二乔斯林肾脏研究。获得病史和血压、血红蛋白A1 c、白蛋白排泄率、尿酸和胱抑素C血清浓度的测量结果。估计肾小球滤过率测定半胱氨酸蛋白酶抑制剂C为基础的formulation.Results：我们研究了364例正常白蛋白尿和311例微量白蛋白尿患者。这两组的平均肾小球滤过率分别为119和99 ml/min。轻度或中度肾功能受损（
Background and objectives: Early renal function decline begins before the onset of proteinuria in patients with type 1 diabetes. The association of elevated serum uric acid with advanced impaired renal function prompts an examination of its role in early renal function decline in patients before proteinuria develops.Design, setting, participants, & measurements: Patients with type 1 diabetes and normoalbuminuria or microalbuminuria were recruited to the Second Joslin Kidney Study. A medical history and measurements of BP, hemoglobin A1c, albumin excretion rate, and serum concentrations of uric acid and cystatin C were obtained. Estimated glomerular filtration rate was measured by a cystatin C-based formula.Results: We studied 364 patients with normoalbuminuria and 311 patients with microalbuminuria. Mean glomerular filtration rate in these groups was 119 and 99 ml/min, respectively. Mildly or moderately impaired renal function (