Endocytosis proteins and cancer: a potential link?
Endocytosis proteins and cancer: a potential link?
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DOI：
10.1016/s0962-8924(98)01316-6
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发表时间：
1998-08-01
影响因子：
19
通讯作者：
De Camilli, P
中科院分区：
文献类型：
--
作者：
Floyd, S;De Camilli, P
最近的研究表明，多种蛋白质与网格蛋白和网格蛋白接头一起参与受体介导的内吞作用。编码其中一些蛋白质的基因是人类造血系统恶性肿瘤中染色体重排的目标。此外，在人类癌症中还报道了一些内吞蛋白的异常表达或突变。本文讨论了这些观察结果，并阐述了内吞蛋白的异常表达可能参与癌症生物学的潜在机制。
Recent studies have shown that a variety of proteins participate with clathrin and clathrin adaptors in receptor-mediated endocytosis. The genes encoding some of these proteins are targets of chromosomal rearrangements in human haematopoietic malignancies. In addition, abnormal expression or mutation of some endocytosis proteins has been reported in human cancers. This article discusses these observations and elaborates the potential mechanisms by which the abnormal expression of endocytosis proteins might participate in the biology of cancer.