A slug, a fox, a pair of sox: transcriptional responses to neural crest inducing signals.
A slug, a fox, a pair of sox: transcriptional responses to neural crest inducing signals.
复制标题
DOI：
10.1002/bdrc.20011
复制
发表时间：
2004-06-01
期刊：
影响因子：
--
通讯作者：
LaBonne, Carole
中科院分区：
文献类型：
--
作者：
Heeg-Truesdell, Elizabeth;LaBonne, Carole
神经嵴是一种仅在脊椎动物胚胎中发现的细胞类型，它产生了头骨和面部以及大部分周围神经系统的结构，以及脊椎动物特有的其他细胞类型。这些细胞具有重要的临床意义，各种各样的先天性缺陷是由于异常的神经嵴发育。越来越多的研究有助于我们了解这组细胞在正常发育过程中如何形成和分化。Wnt、FGF、BMP和Notch介导的信号都在这个过程中发挥重要作用，并且这些信号中的几个似乎发挥多个时间上不同的作用。神经嵴细胞对相同信号的反应随时间的变化可能部分地由这些细胞内表达的不断变化的转录因子的混合物介导。因此，神经嵴发育是一个复杂的多步骤过程，阐明介导该过程不同方面的分子机制将需要我们确定这些因素中每一个单独或组合的作用。在这里，我们回顾了一些最近的进展，我们了解的信号和下游转录因子参与神经嵴细胞的形成。
The neural crest, a cell type found only in vertebrate embryos, gives rise to the structures of the skull and face and most of the peripheral nervous system, as well as other cell types characteristic of vertebrates. These cells are of great clinical significance and a wide variety of congenital defects are due to aberrant neural crest development. Increasing numbers of studies are contributing to our understanding of how this group of cells form and differentiate during normal development. Wnt, FGF, BMP, and Notch-mediated signals all have essential roles in this process, and several of these signals appear to play multiple temporally distinct roles. Changes in the response of neural crest cells to the same signal over time may be mediated, in part, by an ever-changing cocktail of transcription factors expressed within these cells. Neural crest development is thus a complex multistep process, and elucidating the molecular mechanisms that mediate distinct aspects of this process will require that we determine the role of each of these factors alone and in combination. Here, we review some recent advances in our understanding of the signals and downstream transcription factors involved in neural crest cell formation.