The impact of the Cancer Genome Atlas on lung cancer.
The impact of the Cancer Genome Atlas on lung cancer.
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DOI：
10.1016/j.trsl.2015.08.001
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Huang RS
中科院分区：
文献类型：
--
作者：
Chang JT;Lee YM;Huang RS
迄今为止，癌症基因组图谱（TCGA）已经分析了来自33种癌症的10，000多个样本，目的是提高我们对癌症分子基础的理解，并提高我们诊断，治疗和预防癌症的能力。本综述的重点是肺癌，因为它是全球男性和女性癌症相关死亡率的主要原因。特别地，评价了非小细胞肺癌（包括肺腺癌和肺鳞状细胞癌）。我们的目标是展示TCGA在四个主题下对肺癌研究的影响：即诊断标志物，疾病进展标志物，新的治疗靶点和新的工具。给出了与DNA突变、拷贝数变异、mRNA和microRNA表达沿着甲基化谱相关的实例。
The Cancer Genome Atlas (TCGA) has profiled over 10,000 samples derived from 33 types of cancer to date, with the goal of improving our understanding of the molecular basis of cancer and advancing our ability to diagnose, treat, and prevent cancer. This review focuses on lung cancer as it is the leading cause of cancer-related mortality worldwide in both men and women. Particularly, non-small cell lung cancers (including lung adenocarcinoma and lung squamous cell carcinoma) were evaluated. Our goal is to demonstrate the impact of TCGA on lung cancer research under four themes: namely, diagnostic markers, disease progression markers, novel therapeutic targets, and novel tools. Examples were given related to DNA mutation, copy number variation, mRNA, and microRNA expression along with methylation profiling.