Generic brain activation mapping in functional magnetic resonance imaging: A nonparametric approach
Generic brain activation mapping in functional magnetic resonance imaging: A nonparametric approach
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DOI：
10.1016/s0730-725x(97)00135-5
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发表时间：
1997-01-01
影响因子：
2.5
通讯作者：
RabeHesketh, S
中科院分区：
文献类型：
--
作者：
Brammer, MJ;Bullmore, ET;RabeHesketh, S
我们报告了一种识别功能性磁共振成像数据中周期性实验设计一般激活的脑区域的新方法，这涉及：1)在标准空间中注册N个单独的功能性磁共振成像数据集；2)计算对试验设计的标准化响应功率的中位数；3)在无实验效应的零假设下，根据其非参数确定的分布检验每个体素的中位数标准化功率；4)构建通用脑激活图，通过对已知零假设成立条件下获得的6张零图像进行分析，验证了该方法的有效性；通过周期性的听觉语言刺激获得8个图像；和6幅在定期执行隐蔽语言流畅性任务时获得的图像，(C) 1997 Elsevier Science Inc.。
We report a novel method to identify brain regions generically activated by periodic experimental design in functional magnetic resonance imaging data, This involves: 1) registering each of N individual functional magnetic resonance imaging datasets in a standard space; 2) computing the median standardised power of response to the experimental design; 3) testing median standardised power at each voxel against its nonparametrically ascertained distribution under the null hypothesis of no experimental effect; and 4) constructing a generic brain activation map, The method is validated by analysis of 6 null images, acquired under conditions when the null hypothesis was known to be true; 8 images acquired during periodic auditory-verbal stimulation; and 6 images acquired during periodic performance of a covert verbal fluency task, (C) 1997 Elsevier Science Inc.