Hippocampal structures: anteroposterior N-acetylaspartate differences in patients with epilepsy and control subjects as shown with proton MR spectroscopic imaging.
Hippocampal structures: anteroposterior N-acetylaspartate differences in patients with epilepsy and control subjects as shown with proton MR spectroscopic imaging.
复制标题
海马结构：质子磁共振波谱成像显示癫痫患者和对照受试者的前后 N-乙酰天冬氨酸差异。
DOI：
10.1148/radiology.214.2.r00fe43403
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Weiner,MW
中科院分区：
文献类型：
--
作者：
Vermathen,P;Laxer,KD;Matson,GB;Weiner,MW
目的：确定质子代谢物沿海马长轴的分布。材料和方法：对 14 名对照受试者和 9 名单侧内侧颞叶癫痫患者的海马进行质子磁共振 (MR) 波谱成像测量。结果：对照受试者的 N-乙酰天门冬氨酸 (NAA) 与 N-乙酰天门冬氨酸 (NAA) 的比率显着降低。 与海马后部相比，前部含有胆碱化合物 (Ch) 和肌酸加磷酸肌酸 (CR) (NAA/[Cr + Ch])。此外，患者同侧和对侧海马的 NAA/(Cr + Ch) 值存在类似的前后位 (AP) 差异。与对照组相比，患者海马组织各部位同侧NAA/(Cr+Ch)水平均降低，平均降低17%，对侧NAA/(Cr+Ch)水平降低约10%。与对照组相比，患者中海马前区体素的同侧 NAA/(Cr + Ch) 比例降低最大。 结论：AP 差异可能是由于前海马区神经元数量少于后海马区，或者海马体厚度从后到前增加，从而导致相邻海马区的贡献不同。 组织。 T2 的测量表明 T2 差异可能不是造成这些变化的原因。
PURPOSE:To determine the distribution of proton metabolites along the long axis of the hippocampus.MATERIALS AND METHODS:Proton magnetic resonance (MR) spectroscopic imaging measurements were performed in the hippocampi of 14 control subjects and nine patients with unilateral mesial temporal lobe epilepsy.RESULTS:Control subjects showed significantly lower ratios ofN-acetylaspartate (NAA) to choline-containing compounds (Ch) and creatine plus phosphocreatine (CR) (NAA/[Cr + Ch]) in the anterior as compared with the posterior part of the hippocampus. Furthermore, a similar anteroposterior (AP) difference in NAA/(Cr + Ch) values was found in both ipsilateral and contralateral hippocampi of patients. In the patients compared with the control subjects, ipsilateral NAA/(Cr + Ch) levels were reduced in every part of hippocampal tissue with an average reduction of 17%, and contralateral NAA/(Cr + Ch) was reduced by about 10%. In the patients compared with the control subjects, the proportional reduction in ipsilateral NAA/(Cr + Ch) was greatest in voxels from anterior hippocampal regions.CONCLUSION:AP differences could be a result of fewer neurons in the anterior compared with the posterior hippocampus or of the increasing thickness of the hippocampus from posterior to anterior, which leads to different contributions from adjacent tissue. Measurements of T2 showed that T2 differences are probably not responsible for these changes.