A comparison of meconium, maternal urine and neonatal urine for detection of maternal drug use during pregnancy.
A comparison of meconium, maternal urine and neonatal urine for detection of maternal drug use during pregnancy.
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胎便、母体尿液和新生儿尿液的比较，用于检测母体妊娠期间的药物使用情况。
DOI：
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发表时间：
1994
影响因子：
1.6
通讯作者：
J. J. Yoon
中科院分区：
文献类型：
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作者：
William E. Wingert;Michael S. Feldman;Maehee Kim;Lawrence Noble;I. Hand;J. J. Yoon
进行了一项大规模的药物筛选研究，以确定大都市产科人群的药物使用流行率。从 423 次连续分娩中收集胎便、首次排尿以及母尿。尿液样本和胎便甲醇提取物最初通过酶倍增免疫分析技术 (EMIT) 进行筛选，然后通过气相色谱/质谱 (GC/MS) 进行确认。该研究包括可卡因代谢物苯甲酰高宁、大麻素羧基四氢大麻酚、可待因、吗啡和美沙酮的分析。胎便、母体尿液和新生儿尿液中苯甲酰爱康宁的阳性率几乎相同（12%）。研究发现，对于苯甲酰爱康宁的检测，胎便分析比母体或新生儿尿液分析更可靠。在检测大麻素、可待因、吗啡或美沙酮方面，胎便似乎并没有比母体或新生儿尿液更有优势。
A large scale drug screening study was done to determine the prevalence of drug use in a large metropolitan, obstetric population. Meconium and first voided urine, as well as maternal urine were collected from 423 consecutive deliveries. Urine samples and methanolic extracts of meconium were initially screened by Enzyme Multiplied Immunoassay Technique (EMIT) and then confirmed by Gas Chromatography/Mass Spectrometry (GC/MS). Analysis of cocaine metabolite as benzoylecogonine, cannabinoid as carboxy-THC, codeine, morphine and methadone were included in the study. The positive rate for benzoylecgonine was virtually identical for meconium, maternal urine and neonatal urine (12%). Analysis of meconium was found to be more reliable than analysis of maternal or neonatal urine for the detection of benzoylecgonine. Meconium did not appear to offer an advantage over maternal or neonatal urine for detection of cannabinoid, codeine, morphine, or methadone.