Psychometric evaluation of the Major Depression Inventory (MDI) as depression severity scale using the LEAD (Longitudinal Expert Assessment of All Data) as index of validity
Psychometric evaluation of the Major Depression Inventory (MDI) as depression severity scale using the LEAD (Longitudinal Expert Assessment of All Data) as index of validity
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DOI：
10.1186/s12888-015-0529-3
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发表时间：
2015-08-05
期刊：
影响因子：
4.4
通讯作者：
Soendergaard, S.
中科院分区：
文献类型：
--
作者：
Bech, Per;Timmerby, N.;Soendergaard, S.
背景：重度抑郁量表（MDI）的开发是为了涵盖DSM-IV重度抑郁症以及ICD-10轻度、中度和重度抑郁症的抑郁症状。本研究的目的是评估MDI作为抑郁严重程度量表的标准化，使用视觉模拟量表（VAS）作为外部效度指标，按照LEAD方法（所有数据的纵向专家评估）。方法：我们使用了先前发表的两项研究的数据，其中患者进行了MINI神经精神病学访谈，证实了DSM-IV重度抑郁症的诊断。采用无、轻度、中度和重度抑郁的常规VAS评分对MDI进行标准化。结果：MDI与临床医生评分（VAS、MES、HAM-D17和HAM-D6）的相关性在评分周内Pearson系数增加。治疗9周后，系数从0.74到0.83不等。采用临床评定的VAS抑郁严重程度量表，确定无抑郁或可疑抑郁、轻度、中度和重度抑郁的常规MDI分值。结论：采用VAS作为外部、临床效度指标，MDI标准化作为抑郁严重程度的衡量标准是可以接受的，轻度抑郁的MDI分值为21分，中度抑郁的MDI分值为26分，重度抑郁的MDI分值为31分。
Background: The Major Depression Inventory (MDI) was developed to cover the universe of depressive symptoms in DSM-IV major depression as well as in ICD-10 mild, moderate, and severe depression. The objective of this study was to evaluate the standardization of the MDI as a depression severity scale using the Visual Analogue Scale (VAS) as index of external validity in accordance with the LEAD approach (Longitudinal Expert Assessment of All Data).Methods: We used data from two previously published studies in which the patients had a MINI Neuropsychiatric Interview verified diagnosis of DSM-IV major depression. The conventional VAS scores for no, mild, moderate, and severe depression were used for the standardization of the MDI.Results: The inter-correlation for the MDI with the clinician ratings (VAS, MES, HAM-D17 and HAM-D6) increased over the rating weeks in terms of Pearson coefficients. After nine weeks of therapy the coefficient ranged from 0.74 to 0.83. Using the clinician-rated VAS depression severity scale, the conventional MDI cut-off scores for no or doubtful depression, and for mild, moderate and severe depression were confirmed.Conclusions: Using the VAS as index of external, clinical validity, the standardization of the MDI as a measure of depression severity was accepted, with an MDI cut-off score of 21 for mild depression, 26 for moderate depression severity, and 31 for severe depression.