PASTEURELLA-MULTOCIDA AND BORDETELLA-BRONCHISEPTICA INFECTIONS IN RABBITS
PASTEURELLA-MULTOCIDA AND BORDETELLA-BRONCHISEPTICA INFECTIONS IN RABBITS
复制标题
DOI：
10.1128/jcm.28.1.70-75.1990
复制
发表时间：
1990-01-01
影响因子：
9.4
通讯作者：
SILBERNAGEL, SM
中科院分区：
文献类型：
--
作者：
DEEB, BJ;DIGIACOMO, RF;SILBERNAGEL, SM
在商业化养兔场对家兔感染多杀性巴氏杆菌和支气管败血波氏杆菌的自然史进行了前瞻性研究。断奶时，约25%的家兔鼻腔感染多杀性巴氏杆菌，75%的家兔感染B。支气管炎断奶兔的感染比母兔的鼻腔感染多。两种感染的兔子比例随着年龄的增长而增加。在2 ~ 4月龄时，约50%的兔感染多杀性巴氏杆菌或多杀性巴氏杆菌和B。支气管败血症感染的兔发生上呼吸道疾病（URD），而B.支气管败血症感染无发病。在10月龄左右的家兔中，75%为多杀性巴氏杆菌或多杀性巴氏杆菌和B。支气管败血症感染有URD，而几乎没有与B。支气管败血症感染有疾病。鼻孔、副鼻窦、中耳和肺部疾病与多杀性巴氏杆菌相关，而与B无关。支气管败血症感染在患有鼻部多杀性巴氏杆菌感染的成年家兔中，无论是否有URD体征，约80%的家兔同时感染了副鼻窦和中耳，20%的家兔同时感染了支气管和肺部。在无鼻部多杀性巴氏杆菌感染的家兔中，20 - 35%的家兔副鼻窦和中耳有多杀性巴氏杆菌感染。有和没有多杀性巴氏杆菌感染的断奶兔具有相似的免疫球蛋白G（IgG）水平。在前瞻性观察的家兔中，一过性和持续性感染多杀性巴氏杆菌的家兔之间的唯一抗体差异是鼻灌洗液中伊加反应减弱和一过性感染家兔血清中IgM反应提前。IgG水平随着感染持续时间的增加而增加。免疫球蛋白水平与无多杀性巴氏杆菌感染之间没有关系。
The natural history of infection with Pasteurella multocida and Bordetella bronchiseptica in domestic rabbits was studied prospectively at a commercial rabbitry. At weaning, about 25% of rabbits had nasal infections with P. multocida and 75% had infections with B. bronchiseptica. Infection of weanling rabbits paralleled nasal infections of their dams. The proportion of rabbits with both infections increased with age. At 2 to 4 months old, about 50% of rabbits with P. multocida or P. multocida and B. bronchiseptica infections had upper respiratory disease (URD), whereas rabbits with B. bronchiseptica infection had no disease. In rabbits about 10 months old, 75% with P. multocida or P. multocida and B. bronchiseptica infection had URD, whereas virtually none with B. bronchiseptica infection had disease. Disease of the nares, paranasal sinuses, middle ears, and lungs was associated with P. multocida and not B. bronchiseptica infection. In adult rabbits with nasal P. multocida infection, with or without signs of URD, about 80% had concurrent infection of the paranasal sinuses and middle ears and 20% had infection of the bronchi and lungs. In rabbits without nasal P. multocida infection, 20 to 35% had P. multocida infection of the paranasal sinuses and middle ears. Weanling rabbits with and without P. multocida infection had similar immunoglobulin G (IgG) levels. In rabbits observed prospectively, the only antibody differences between those transiently and persistently infected with P. multocida were a diminished IgA response in nasal lavages and an earlier IgM response in sera of transiently infected rabbits. IgG levels increased with the duration of infection. There was no relationship between immunoglobulin levels and freedom from P. multocida infection.