Bacterial invasion:: Force feeding by Salmonella

Bacterial invasion:: Force feeding by Salmonella
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DOI:
10.1016/s0960-9822(99)80178-x
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发表时间:
1999-04-22
期刊:
影响因子:
9.2
通讯作者:
Finlay, BB
Finlay, BB
中科院分区:
生物学1区
文献类型:
--
作者:
Brumell, JH;Steele-Mortimer, O;Finlay, BB

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最近的研究结果为沙门氏菌入侵大肠杆菌细胞提供了新的线索。使用III型分泌系统,沙门氏菌将毒力因子递送到宿主细胞中,所述毒力因子直接激活信号转导途径,通过皱褶机制启动细胞骨架重排和细菌摄取。
Recent findings have shed new light on mammalian-cell invasion by Salmonella. Using a type III secretion system, Salmonella deliver virulence factors into the host cell that directly activate signal transduction pathways, initiating cytoskeletal rearrangements and bacterial uptake by a ruffling mechanism.