Soft Bacterial Cellulose Microcapsules with Adaptable Shapes
Soft Bacterial Cellulose Microcapsules with Adaptable Shapes
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DOI：
10.1021/acs.biomac.9b01143
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发表时间：
2019-12-01
影响因子：
6.2
通讯作者：
Spicer, Patrick T.
中科院分区：
文献类型：
--
作者：
Song, Jie;Babayekhorasani, Firoozeh;Spicer, Patrick T.
具有可控稳定性和渗透性的微胶囊在分离和封装应用中具有很高的需求。我们已经开发了一种生物界面的过程，以制造强大的，但灵活的，多孔的微胶囊从细菌纤维素在油/水乳液界面。已成功生产出直径从100微米到5厘米的多种微胶囊尺寸。使用共聚焦显微镜对三维胶囊微观结构进行成像，显示出高度多孔的约30 μ m的纤维素膜厚度，具有大于0.5 μ m的一些孔，这些孔通过自由扩散可渗透大多数大分子，但可以排除较大的结构如细菌。纤维素微胶囊的机械变形揭示了它们的柔韧性，使它们能够通过弯曲和折叠而通过比其初始尺寸小得多的直径的收缩。我们的工作提供了一种新的方法来生产软，渗透性和生物相容性的微胶囊物质封装和保护。这些胶囊可以在商业应用中替代悬浮的聚合物珠，并有可能作为人工细胞的框架。
Microcapsules with controlled stability and permeability are in high demand for applications in separation and encapsulation. We have developed a biointerfacial process to fabricate strong, but flexible, porous microcapsules from bacterial cellulose at an oil water emulsion interface. A broad range of microcapsule sizes has been successfully produced, from 100 mu m to 5 cm in diameter. The three-dimensional capsule microstructure was imaged using confocal microscopy, showing a cellulose membrane thickness of around 30 mu m that is highly porous, with some pores larger than 0.5 mu m that are permeable to most macromolecules by free diffusion but can exclude larger structures like bacteria. The mechanical deformation of cellulose microcapsules reveals their flexibility, enabling them to pass through constrictions with a much smaller diameter than their initial size by bending and folding. Our work provides a new approach for producing soft, permeable, and biocompatible microcapsules for substance encapsulation and protection. The capsules may offer a replacement for suspended polymer beads in commercial applications and could potentially act as a framework for artificial cells.