Low glomerular filtration in the population: Prevalence, associated disorders, and awareness
Low glomerular filtration in the population: Prevalence, associated disorders, and awareness
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DOI：
10.1038/sj.ki.5001641
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发表时间：
2006-08-01
影响因子：
19.6
通讯作者：
De Santo, N. G.
中科院分区：
文献类型：
--
作者：
Cirillo, M.;Laurenzi, M.;De Santo, N. G.
在美国，估计肾小球滤过率（eGFR）被用来分析肾脏疾病的患病率。该研究调查了意大利人群样本的患病率、相关疾病和肾脏疾病意识。收集了Gubbio人群研究（n = 4574，男女，年龄18-95岁）的血清肌酐、其他实验室指标、血压和病史数据。分析了eGFR（肾脏疾病研究中的改良饮食方程）、可能继发于肾功能障碍的疾病（高血压、高血尿酸、高血磷/低血钙、高血钾、心血管疾病、贫血）和肾脏疾病意识。eGFR < 60 ml/min × 1.73 m(2)的患病率随着年龄的增长而增加（从18-24岁的< 1%到>= 75岁的430%，P < 0.001）。在eGFR < 60 ml/min x 1.73 m(2)组中，大多数人继发肾功能障碍的数量为>= 2，高于eGFR >= 60 ml/min x 1.73 m(2)组（P < 0.001），且与eGFR呈负相关（P < 0.001）。eGFR < 60 ml/min × 1.73 m组报告的肾脏疾病患病率为3.3%(2)，与血清肌酐和继发肾功能障碍数量直接相关（P < 0.001）。肾功能低下在老年人群中很常见，并与典型的肾脏疾病有关。肾功能低下的人很少意识到肾脏疾病，除非血清肌酐非常高或存在许多肾脏疾病的典型疾病。
Estimated glomerular filtration rate (eGFR) was used for analysis of kidney disease prevalence in the United States. The study investigated on prevalence, associated disorders, and kidney disease awareness in an Italian population sample. Data were collected on serum creatinine, other laboratory indices, blood pressure, and medical history in the Gubbio Population Study (n = 4574, both sexes, ages 18-95 years). Analyses were carried out on eGFR ( equation of Modification Diet in Renal Disease study), disorders potentially secondary to kidney dysfunction (hypertension, high serum uric acid, high serum phosphorus/low serum calcium, high serum potassium, cardiovascular disease, anemia), and kidney disease awareness. The prevalence of eGFR < 60 ml/min x 1.73 m(2) increased with age in both sexes ( from < 1% for ages 18-24 years to 430% for ages >= 75 years, P < 0.001). In the group with eGFR < 60 ml/min x 1.73 m(2), number of disorders secondary to kidney dysfunction was >= 2 in the majority of persons, was higher than in persons with eGFR >= 60 ml/min x 1.73 m(2) (P < 0.001), and was inversely related to eGFR (P < 0.001). The prevalence of reported kidney disease was 3.3% in the group with eGFR < 60 ml/min x 1.73 m(2) and directly related to serum creatinine and number of disorders secondary to kidney dysfunction (P < 0.001). Low kidney function is frequent in the older population and is associated with disorders typical of kidney disease. Persons with low kidney function are rarely aware of kidney disease unless of very high serum creatinine or presence of many disorders typical of kidney disease.