Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin
Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin
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DOI：
10.1002/biof.552210136
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发表时间：
2004-01-01
期刊：
影响因子：
6
通讯作者：
Igarashi, K
中科院分区：
文献类型：
--
作者：
Murakami, T;Miyakoshi, M;Igarashi, K
研究了蛇葡萄叶、茎及其主要成分蛇葡萄素对d -半乳糖胺所致大鼠肝损伤的保护作用。饲粮中添加50%乙醇提取物（1%）和蛇葡萄素（0.1%）可显著抑制GalN处理引起的LDH、ALT、AST、α -生育酚水平和GSG/GSSH升高。这些结果表明，茶蛇葡萄素可以防止体内氧化应激，这可能是由于巨噬细胞通过GalN的作用形成活性氧所致。
Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, alpha-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.