Towards a better understanding of carotenoid metabolism in animals.
Towards a better understanding of carotenoid metabolism in animals.
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DOI：
10.1016/j.bbadis.2004.11.010
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发表时间：
2005-05
期刊：
影响因子：
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通讯作者：
J. von Lintig;Susanne Hessel;Andrea Isken;Cornelia Kiefer;J. Lampert;Olaf Voolstra;K. Vogt
中科院分区：
文献类型：
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作者：
J. von Lintig;Susanne Hessel;Andrea Isken;Cornelia Kiefer;J. Lampert;Olaf Voolstra;K. Vogt
维生素A衍生物（类维生素A）是视觉的重要组成部分;它们有助于发育过程中的图案形成，并对细胞分化产生多种影响，具有重要的临床意义。所有天然存在的维生素A都是通过酶促氧化裂解从具有维生素A原活性的类胡萝卜素中获得的。为了具有生物活性，这些植物来源的化合物必须首先被吸收，然后被输送到体内的作用部位，并通过代谢转化为真实的维生素。最近，通过对果蝇突变体的分析，确定了这一途径的分子参与者。在脊椎动物中也发现了类似的基因组序列。随后，克隆了这些同源基因，并对其基因产物进行了功能表征。本文综述了维生素A生物合成途径的最新研究进展，并对类胡萝卜素及其衍生物的生物化学、生理学、发育学和医学等方面进行了讨论。
Vitamin A derivatives (retinoids) are essential components in vision; they contribute to pattern formation during development and exert multiple effects on cell differentiation with important clinical implications. All naturally occurring vitamin A derives by enzymatic oxidative cleavage from carotenoids with provitamin A activity. To become biologically active, these plant-derived compounds must first be absorbed, then delivered to the site of action in the body, and metabolically converted to the real vitamin. Recently, molecular players of this pathway were identified by the analysis of blind Drosophila mutants. Similar genome sequences were found in vertebrates. Subsequently, these homologous genes were cloned and their gene products were functionally characterized. This review will summarize the advanced state of knowledge about the vitamin A biosynthetic pathway and will discuss biochemical, physiological, developmental and medical aspects of carotenoids and their numerous derivatives.