The effect of miglitol and acarbose after an oral glucose load: a novel hypoglycaemic mechanism?
The effect of miglitol and acarbose after an oral glucose load: a novel hypoglycaemic mechanism?
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口服葡萄糖负荷后米格列醇和阿卡波糖的作用：一种新的降血糖机制？
DOI：
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发表时间：
1990
影响因子：
3.4
通讯作者：
GN Foukaridis
中科院分区：
文献类型：
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作者：
P. Joubert;H. Venter;GN Foukaridis
1. α -葡萄糖苷酶抑制剂如米格列醇和阿卡波糖通过干扰胃肠道中双糖向单糖的转化来降低健康志愿者和糖尿病患者淀粉负荷后的血糖。2. 在9名健康的高加索志愿者中，研究了安慰剂、100mg米格列醇和100mg阿卡波糖在75g口服葡萄糖负荷前30分钟给予的效果。3. 与安慰剂和阿卡波糖相比，米格列醇能显著降低峰后血糖水平。血清胰岛素无明显变化。4. 由于米格列醇具有良好的吸收性，而阿卡波糖则不然，因此有人认为米格列醇具有全身降糖作用，这可能与米格列醇与葡萄糖的结构相似有关，有待进一步研究。
1. Alpha-glucosidase inhibitors such as miglitol and acarbose lower blood glucose after a starch load in healthy volunteers and diabetic patients by interfering with the conversion of disaccharide to monosaccharide in the gastrointestinal tract. 2. The effect of placebo, 100 mg miglitol and 100 mg acarbose given 30 min prior to a 75 g oral glucose load was investigated in nine healthy Caucasian volunteers. 3. Miglitol produced a statistically significant fall in post-peak blood glucose levels when compared with placebo and acarbose. Serum insulin did not change significantly. 4. As miglitol is well absorbed and acarbose is not, it is suggested that miglitol has a systemic hypoglycaemic effect, probably related to its close structural similarity to glucose, which warrants further investigation.