Resistance to murine cytomegalovirus linked to the major histocompatibility complex of the mouse.
Resistance to murine cytomegalovirus linked to the major histocompatibility complex of the mouse.
复制标题
对鼠巨细胞病毒的抵抗力与小鼠的主要组织相容性复合体有关。
DOI：
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发表时间：
1977
影响因子：
3.8
通讯作者：
N. Stanley
中科院分区：
文献类型：
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作者：
J. Chalmer;J. Mackenzie;N. Stanley
对近交系小鼠对小鼠巨细胞病毒感染的抗性模式的研究表明，存在耐药株和敏感株。抗药性与小鼠主要组织相容性基因座上的H-2k等位基因有关。抗病品系(C3H/Hej)与感病品系(BALB/c)杂交F1代的抗性介于双亲之间，表明控制抗性的基因(S)部分显性。易感的BALB/c小鼠可以通过硫代乙酸酯肉汤的预处理而不是内毒素或卡介苗的预处理而使其对致死性感染具有抵抗力。用环磷酰胺预处理可使耐药C3H/HeJ小鼠对致死性感染易感。
Studies of the resistance patterns to infection with a murine cytomegalovirus in inbred strains of mice revealed the existence of resistant and susceptible strains. Resistance was found to be associated with possession of the H-2k allele at the major histocompatibility locus of the mouse. The F1 hybrid between a resistant strain (C3H/HeJ) and a susceptible strain (BALB/c) was found to have a resistance intermediate between that of both parents, indicating that the gene(s) controlling resistance is partly dominant. Susceptible BALB/c mice could be made resistant to lethal infection by pre-treatment with thioglycollate broth but not by pre-treatment with endotoxin or BCG. Resistant C3H/HeJ mice could be made susceptible to lethal infection by pre-treatment with cyclophosphamide.