Macrophages and iron trafficking at the birth and death of red cells
Macrophages and iron trafficking at the birth and death of red cells
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DOI：
10.1182/blood-2014-12-567776
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发表时间：
2015-05-07
期刊：
影响因子：
20.3
通讯作者：
Hamza, Iqbal
中科院分区：
文献类型：
--
作者：
Korolnek, Tamara;Hamza, Iqbal
巨噬细胞通过与发育和死亡的红细胞密切相关，在铁稳态中发挥关键作用。中央看护巨噬细胞促进成红细胞岛生态位中的红细胞生成。这些巨噬细胞与成红细胞进行物理接触，使信号传导和生长因子的转移以及可能的营养物质转移到它们所关心的细胞中。人类成熟红细胞在衰老并再次与巨噬细胞接触之前有120天的寿命。红细胞的吞噬作用是体内铁通量的主要来源，因为每个红细胞中的血红素必须从大约2700亿个血红蛋白分子中回收，每秒大约有200万个衰老的红细胞被回收。在这里，我们将审查铁贩运的途径发现在巨噬细胞红细胞轴，重点是血红素在toto运输的可能作用。
Macrophages play a critical role in iron homeostasis via their intimate association with developing and dying red cells. Central nurse macrophages promote erythropoiesis in the erythroblastic island niche. These macrophages make physical contact with erythroblasts, enabling signaling and the transfer of growth factors and possibly nutrients to the cells in their care. Human mature red cells have a lifespan of 120 days before they become senescent and again come into contact with macrophages. Phagocytosis of red blood cells is the main source of iron flux in the body, because heme must be recycled from approximately 270 billion hemoglobin molecules in each red cell, and roughly 2 million senescent red cells are recycled each second. Here we will review pathways for iron trafficking found at the macrophage-erythroid axis, with a focus on possible roles for the transport of heme in toto.