The Distribution of Different Clades of Seneca Valley Viruses in Guangdong Province, China
The Distribution of Different Clades of Seneca Valley Viruses in Guangdong Province, China
复制标题
DOI：
10.1007/s12250-018-0056-8
复制
发表时间：
2018-10-01
影响因子：
5.5
通讯作者：
Zheng, Haixue
中科院分区：
文献类型：
--
作者：
Chen, Pan;Yang, Fan;Zheng, Haixue
塞涅卡谷病毒（SVV）是一种新发现的引起猪水泡病的病毒，可引起猪的特发性疾病和仔猪的急性死亡。最近，在美国和中国报告了越来越多的SVV感染病例，给养猪业造成了重大的经济损失。我国首次在生猪生产大省广东省发现SVV。2015年和2016年广东连续报告SVV病例。不过，2017年广东SVV的传播情况仍不得而知。在本研究中，我们确定了两个新的SVV株，CH-GD-2017-1和CH-GD-2017-2从广东。遗传学分析表明，这两个广东菌株与以前的广东菌株有不同的特征。它们与2015年和2016年分离的菌株的核苷酸相似性较低，与美国菌株更相似。系统发育分析表明，新菌株与广东菌株聚在不同的分支。我们在新毒株中发现了28个突变的氨基酸，与第一个广东毒株SVV CH-01-2015相比。在地理分布上，美国和中国报告的SVV病例数最多，且大多数病例分布在中国东部和中部地区，广东省是SVV的主要流行区之一。综上所述，我们的研究结果表明，2017年SVV在广东省继续传播，并在该地区出现了两个不同的SVV分支。
Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in significant economic losses to the swine industry. The first identification of SVV in China was reported in Guangdong Province, a major swine producing province. The cases of SVV were continuously reported in Guangdong in 2015 and 2016. However, the spread of SVV in Guangdong in 2017 remains unknown. In this study, we determined two new SVV strains, CH-GD-2017-1 and CH-GD-2017-2, from Guangdong. The genetic analysis suggested that the two Guangdong strains showed different characteristics to previous Guangdong strains. They showed lower nucleotide similarity with strains isolated in 2015 and 2016, and were more similar to the US strains. Phylogenetic analyses indicated that the new strains were clustered in a different clade with previous Guangdong strains. We found 28 mutated amino acids in the new strains, compared with the first Guangdong strain, SVV CH-01-2015. In the geographic analysis, we found that the US and China reported more SVV cases than other countries, and most of the SVV cases were reported in east and central Chinaof which, Guangdong Province is one of the major epidemic regions. In conclusion, our findings indicate that SVV continued to spread in Guangdong Province in 2017, and two different clades of SVVs have emerged in this region.