The impact of female gender on bladder cancer-specific death risk after radical cystectomy: a meta-analysis of 27,912 patients
The impact of female gender on bladder cancer-specific death risk after radical cystectomy: a meta-analysis of 27,912 patients
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DOI：
10.1007/s11255-015-0980-6
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发表时间：
2015-06-01
影响因子：
2
通讯作者：
Ding, Qiang
中科院分区：
文献类型：
--
作者：
Liu, Shenghua;Yang, Tian;Ding, Qiang
对女性性别与根治性膀胱切除术后癌症特异性死亡风险之间的关系进行首次荟萃分析。综合检索MEDLINE和EMBASE数据库，检索截止到2014年11月11日发表的相关研究。meta分析采用随机效应方法估计风险比（hr）和置信区间（ci）。荟萃分析共纳入17项研究，共纳入27,912例患者。根治性膀胱切除术后，与男性相比，女性与更差的生存结果相关（合并HR 1.20; 95% CI 1.09-1.32）。亚组分析发现，在北美和欧洲的研究（相对危险度1.17,95% CI 1.02-1.32，相对危险度1.34,95% CI 1.19-1.51）和更大样本的研究（相对危险度1.24,95% CI 1.11-1.38）中，相关性是显著的。我们还发现调整了关键因素（T期、N期和分级）的研究获得了正相关（HR 1.21, 95% CI 1.09-1.35）。女性膀胱癌根治性膀胱切除术后的生存结果比男性更差。建议在根治性膀胱切除术后对女性患者采取更严格的护理。
To perform a first meta-analysis on the association between female gender and cancer-specific death risk after radical cystectomy.A comprehensive literature search of the MEDLINE and EMBASE databases was conducted for relevant studies published till November 11, 2014. The meta-analysis was performed by estimating the hazard ratios (HRs) and confidence intervals (CIs) through a random-effect approach.A total of 17 studies were included in the meta-analysis with a total population of 27,912 patients. Female gender was associated with a worse survival outcome (pooled HR 1.20; 95 % CI 1.09-1.32) compared with male gender after radical cystectomy. Subgroup analysis found the correlation was significant in North American and European studies (HR 1.17, 95 % CI 1.02-1.32 and HR 1.34, 95 % CI 1.19-1.51, respectively) and studies from larger size of samples (HR 1.24, 95 % CI 1.11-1.38). We also found studies adjusted for the key elements (T stage, N stage and grade) obtained positive correlation (HR 1.21, 95 % CI 1.09-1.35).Female demonstrated worse survival outcomes than male after radical cystectomy for bladder cancer. The adoption of more intense cares for female patients was suggested after radical cystectomy.