Vacuum-sealing-technique used as drug release system for topical treatment of wound infections
Vacuum-sealing-technique used as drug release system for topical treatment of wound infections
复制标题
DOI：
10.1007/s001130050318
复制
发表时间：
1998-08-01
期刊：
影响因子：
--
通讯作者：
Stampehl, M
中科院分区：
文献类型：
--
作者：
Fleischmann, W;Russ, M;Stampehl, M
在1996年4月至1997年3月期间，27例急性骨和软组织感染（n = 13）、慢性骨髓炎（n = 8）和慢性伤口（n = 6）患者采用灌注-真空-密封进行治疗。使用带引流管的聚乙烯醇海绵覆盖手术清创后的内外创面。在用透明膜敷料密封地覆盖伤口后，真空源在海绵中产生部分真空，该海绵根据伤口的类型在20和80 kPa之间进行修改。每天数次堵塞真空管路，并以交替方式滴注抗菌剂或抗生素溶液30分钟。然后，重新建立真空，并从伤口排出液体。7天后，停止间歇性药物滴注，通过继发性植皮（n = 22）、皮肤移植（n = 3）或自发上皮形成（n = 2）立即或延迟伤口闭合。在从滴注治疗开始的4.2（3-14）个月的随访期间，1例慢性骨髓炎患者出现1例感染复发。
Between 1.4.96 and 1.3.97 27 patients with acute infections of bone and soft tissues (n = 13), chronic osteomyelitis (n = 8), and chronic wounds (n = 6) were treated by using Instillation-Vacuum-Sealing. Polyvinylalcohol sponges with drainage tubes were used to cover the internal or external wound surfaces which resulted from surgical debridement. Having hermetically covered the wound with a transparent film dressing a vacuum source generated a partial vacuum in the sponge which was modified according to the type of wound between 20 and 80 kPa. Several times daily,the vacuum line was blocked and, in an alternating fashion, antiseptic or antibiotic solution instilled for 30 minutes. Then, the vacuum was reestablished and the fluids drained from the wound. Seven days later, intermittent drug instillation was stopped and there was either immediate or delayed wound closure by secondary suturing (n = 22), skin grafting (n = 3) or spontaneous epithelialization (n = 2). During a follow-up from the beginning of the instillation treatment of 4,2 (3-14) months there was one recurrency of infection in a patient with chronic osteomyelitis.