Blended PCL/PLGA scaffold fabrication using multi-head deposition system
Blended PCL/PLGA scaffold fabrication using multi-head deposition system
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DOI：
10.1016/j.mee.2008.11.026
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发表时间：
2009-04-01
影响因子：
2.3
通讯作者：
Cho, Dong-Woo
中科院分区：
文献类型：
--
作者：
Kim, Jong Young;Cho, Dong-Woo
固体自由形式制造（SFF）技术可以为基于支架的组织工程中受损组织或器官的再生提供很大的机会。在这项研究中，介绍了一种通过多头沉积系统（MHDS）制造用于组织工程的新型混合支架。使用 MHDS 制造 3D 组织支架需要结合多种技术，包括运动控制、热控制、气动控制和 CAD/CAM 软件。混合的3D聚己内酯（PCL）/聚乳酸-乙醇酸（PLGA）支架的均匀孔径为600μm，线宽和高度为200μm，具有完全互连的结构，计算孔隙率约为69.6%。支架的抗压强度和模量分别约为0.8和12.9 MPa，足以在体外细胞实验期间保持其结构。最后，通过细胞增殖实验证明了制造的3D支架的生物相容性。在不久的将来，混合PCL/PLGA支架将成为组织工程支架的良好选择。 (C) 2008 Elsevier B.V. 保留所有权利。
Solid free-form fabrication (SFF) technologies can endow a great chance for regeneration of damaged tissues or organs in scaffold-based tissue engineering. In this study, a novel blended scaffold fabrication through multi-head deposition system (MHDS) for tissue engineering is introduced. Fabrication of 3D tissue scaffolds using MHDS required the combination of several technologies, including motion control, thermal control, pneumatic control, and CAD/CAM software. Blended 3D poly-caprolactone (PCL)/poly-lactic-co-glycolic acid (PLGA) scaffolds with a uniform pore size of 600 mu m and a line width and height of 200 mu m were well fabricated having a fully interconnected architecture and calculated porosity of about 69.6%. The compressive strength and modulus of the scaffold is each about 0.8 and 12.9 MPa, which is enough to maintain its architecture during in vitro cell experiments. Finally, the biocompatibility of fabricated 3D scaffold was demonstrated through the cell proliferation experiment. In the near future, blended PCL/PLGA scaffold will be a good option of scaffold for tissue engineering. (C) 2008 Elsevier B.V. All rights reserved.