Interval hypoxic training improves autonomic cardiovascular and respiratory control in patients with mild chronic obstructive pulmonary disease
Interval hypoxic training improves autonomic cardiovascular and respiratory control in patients with mild chronic obstructive pulmonary disease
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DOI：
10.1097/hjh.0b013e32832c0018
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发表时间：
2009-08-01
影响因子：
4.9
通讯作者：
Bernardi, Luciano
中科院分区：
文献类型：
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作者：
Haider, Thomas;Casucci, Gaia;Bernardi, Luciano
目的慢性阻塞性肺疾病（COPD）与心脏自主神经系统失调有关。本研究评估间歇低氧训练对轻度COPD患者心血管和呼吸控制的影响。方法将18例常压轻度COPD患者（年龄51.7 +/- 2.4岁，平均+/- SEM）随机分配到训练组或安慰剂组，以及14例年龄匹配的健康对照组（47.7 +/- 2.8岁），监测潮末二氧化碳、气道流量、动脉血氧饱和度、心电图和静止时连续无创血压。在进行性高碳酸血症高氧和等碳酸血症低氧期间，比较低氧训练前后3周对低氧和高碳酸血症的气压反射敏感性。在双盲方式下，两组均接受15次被动间歇缺氧（训练组）或正常缺氧（安慰剂组）。对于低氧组，每个疗程包括3-5个低氧（15-12%氧气）周期（3-5分钟）和3分钟的正常氧间隔。安慰剂组吸入常温空气。结果在训练前，COPD患者与健康人相比，压力反射敏感性降低，无明显的化学反射异常。训练后，与安慰剂组相比，训练组的神经功能明显增加(P
Objectives Chronic obstructive pulmonary disease (COPD) is associated with cardiac autonomic nervous system dysregulation. This study evaluates the effects of interval hypoxic training on cardiovascular and respiratory control in patients with mild COPD.Methods In 18 eucapnic normoxic mild COPD patients (age 51.7 +/- 2.4 years, mean +/- SEM), randomly assigned to either training or placebo group, and 14 age-matched healthy controls (47.7 +/- 2.8 years), we monitored end-tidal carbon dioxide, airway flow, arterial oxygen saturation, electrocardiogram, and continuous noninvasive blood pressure at rest, during progressive hypercapnic hyperoxia and isocapnic hypoxia to compare baroreflex sensitivity to hypoxia and hypercapnia before and after 3 weeks of hypoxic training. In double-blind fashion, both groups received 15 sessions of passive intermittent hypoxia (training group) or normoxia (placebo group). For the hypoxia group, each session consisted of three to five hypoxic (15-12% oxygen) periods (3-5 min) with 3-min normoxic intervals. The placebo group inhaled normoxic air.Results Before training, COPD patients showed depressed baroreflex sensitivity, as compared with healthy individuals, without evident chemoreflex abnormalities. After training, in contrast to placebo group, the training group showed increased (P