Sequence of developmental alterations following acute ethanol exposure in mice: craniofacial features of the fetal alcohol syndrome.
Sequence of developmental alterations following acute ethanol exposure in mice: craniofacial features of the fetal alcohol syndrome.
复制标题
小鼠急性乙醇暴露后发育变化的序列：胎儿酒精综合征的颅面特征。
DOI：
10.1002/aja.1001660303
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Johnston,MC
中科院分区：
文献类型：
--
作者：
Sulik,KK;Johnston,MC
在胚胎发育的原肠胚形成阶段，用急性母体乙醇给药在C57 B1/6 J小鼠中诱导胎儿酒精综合征（FAS）的典型面部特征。这些特征包括小头畸形、小眼畸形、睑裂短、中区缺陷和上唇长。扫描电子显微镜（SEM）分析胚胎24小时后，最初的乙醇暴露在妊娠7天0小时，发现一个明显的尺寸减小的神经板，这是特别明显的前脑区。正如预期的那样，在这些早期阶段神经板发育的缺陷导致异常的大脑和眼睛形成。对胚胎后期的扫描电子显微镜分析显示，嗅觉基板发育紧密，导致内侧鼻突（该区域负责形成上唇的中区、包含上切牙的牙槽嵴和硬腭的前部-初级腭）的缺陷。受影响的新生儿清除骨骼准备有显着的前颌骨骨缺损。一种最常见的已知人类致畸剂对原肠胚具有重大的畸形诱导作用，原肠胚是大多数女性识别妊娠前人类胚胎中存在的发育阶段。
The typical facial features of the fetal alcohol syndrome (FAS) were induced in C57B1/6J mice with acute maternal ethanol administration at gastrulation stages of embryonic development. These features include microcephaly, microphthalmia, short palpebral fissures, deficiencies of the philtral region, and a long upper lip. Scanning electron microscopic (SEM) analysis of embryos 24 hours following initial ethanol exposure at 7 days 0 hours of gestation revealed an obvious size reduction in the neural plate, which was particularly noticeable in the forebrain region. As expected, deficiencies in neural plate development at these early stages result in abnormal brain and eye formation. SEM analysis of later embryonic stages revealed the development of closely set olfactory placodes with resultant deficiencies in the medial nasal prominences (that area responsible for forming the philtral region of the upper lip, the alveolar ridge containing the upper incisors, and the anterior portion of the hard palate—the primary palate). Cleared skeletal preparations of affected newborns had marked premaxillary bone deficiencies. One of the most prevalent known human teratogens has a major malformation‐inducing effect on gastrulating embryos, a developmental stage present in human embryos prior to pregnancy recognition by most women.