Pulse wave velocity and carotid atherosclerosis in white and Latino patients with hypertension.
Pulse wave velocity and carotid atherosclerosis in white and Latino patients with hypertension.
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DOI：
10.1186/1471-2261-11-15
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发表时间：
2011-04-11
影响因子：
2.1
通讯作者：
Havranek EP
中科院分区：
文献类型：
--
作者：
Krantz MJ;Long CS;Hosokawa P;Karimkahani E;Dickinson M;Estacio RO;Masoudi FA;Havranek EP
预防心脏病学已从冠心病扩展到预防更广泛的心血管疾病。少数族裔患冠状动脉外血管疾病（包括心力衰竭和脑血管疾病）的风险相对较高。我们对安全网医疗保健系统中的拉丁裔和白人高血压患者进行了一项横断面研究。测量弗雷明汉危险因素、炎症标志物（hsCRP、LPpLA2）、动脉僵硬度（脉搏波速度、增强指数和中央主动脉压）和内皮功能（肱动脉血流介导的扩张）。对这些参数与冠状动脉外动脉粥样硬化指数（颈动脉内膜中层厚度）之间进行单变量和多变量关联。在 177 名受试者中，平均年龄为 62 岁，其中 67% 为女性，67% 为拉丁裔。在单变量分析中，与 p < 0.25 的颈动脉内膜中层厚度 (IMT) 相关的标志物包括脉搏波速度 (PWV)、增强指数 (AIx)、中心主动脉压 (cAP) 和 LpPLA2 活动等级。然而，调整 Framingham 危险因素后，AIx、cAP 和 LpPLA2 活性与颈动脉 IMT 不显着相关（所有 p > .10）。只有 PWV 与颈动脉 IMT 保持显着相关性，与 Framingham 一般风险概况参数无关 (p = .016)。没有观察到弗雷明汉和其他自变量与种族之间存在统计学上显着的交互作用（所有 p > .05）。在这个安全网队列中，PWV 是一种潜在有用的辅助动脉粥样硬化风险标记，与传统风险因素和种族无关。
Preventive cardiology has expanded beyond coronary heart disease towards prevention of a broader spectrum of cardiovascular diseases. Ethnic minorities are at proportionately greater risk for developing extracoronary vascular disease including heart failure and cerebrovascular disease. We performed a cross sectional study of Latino and White hypertension patients in a safety-net healthcare system. Framingham risk factors, markers of inflammation (hsCRP, LPpLA2), arterial stiffness (Pulse wave velocity, augmentation index, and central aortic pressure), and endothelial function (brachial artery flow-mediated dilatation) were measured. Univariate and multivariable associations between these parameters and an index of extracoronary atherosclerosis (carotid intima media thickness) was performed. Among 177 subjects, mean age was 62 years, 67% were female, and 67% were Latino. In univariate analysis, markers associated with carotid intima media thickness (IMT) at p < 0.25 included pulse wave velocity (PWV), augmentation index (AIx), central aortic pressure (cAP), and LpPLA2 activity rank. However, AIx, cAP, and LpPLA2 activity were not significantly associated with carotid IMT after adjusting for Framingham risk factors (all p > .10). Only PWV retained a significant association with carotid IMT independent of the Framingham general risk profile parameters (p = .016). No statistically significant interactions between Framingham and other independent variables with ethnicity (all p > .05) were observed. In this safety net cohort, PWV is a potentially useful adjunctive atherosclerotic risk marker independent of traditional risk factors and irrespective of ethnicity.
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影响因子：
37.8
作者：
Mitchell GF;Hwang SJ;Vasan RS;Larson MG;Pencina MJ;Hamburg NM;Vita JA;Levy D;Benjamin EJ
通讯作者：
Benjamin EJ
影响因子：
8.3
作者：
OLEARY, DH;POLAK, JF;MANOLIO, TA
通讯作者：
MANOLIO, TA
影响因子：
8.3
作者：
Mannheim, Dallit;Herrmann, Joerg;Lerman, Amir
通讯作者：
Lerman, Amir
影响因子：
5
作者：
Rodondi, Nicolas;Marques-Vidal, Pedro;Newman, Anne B.
通讯作者：
Newman, Anne B.
影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB