Physiological and pathological population dynamics of circulating human red blood cells
Physiological and pathological population dynamics of circulating human red blood cells
复制标题
DOI：
10.1073/pnas.1012747107
复制
发表时间：
2010-11-23
影响因子：
11.1
通讯作者：
Mahadevan, L.
中科院分区：
文献类型：
--
作者：
Higgins, John M.;Mahadevan, L.
控制人类红细胞(RBC)群体的数量、大小和血红蛋白浓度的系统及其在贫血中的失调，目前还知之甚少。当红细胞从骨髓中释放出来后，由于一种未知的机制，红细胞体积和总血红蛋白含量都会降低[Lew VL，et al.(1995)血液86：334-341；Waugh RE等人。(1992)血液79：1351-1358]；在类似的120d后，对未知的触发作出反应，它们被移除。我们使用统计物理学的理论和医院临床实验室的数据[d‘OnoFrio G，et al.(1995)血液85：818-823]建立红细胞成熟和清除的主方程模型。该模型准确地识别了贫血患者，并区分了地中海贫血特质贫血和缺铁性贫血。引人注目的是，它还能在临床可检测到贫血的几周前识别出许多贫血前期患者。更广泛地说，我们说明了如何使用临床实验室数据来开发和测试具有潜在临床实用价值的人类病理生理学的动态模型。
The systems controlling the number, size, and hemoglobin concentrations of populations of human red blood cells (RBCs), and their dysregulation in anemia, are poorly understood. After release from the bone marrow, RBCs undergo reduction in both volume and total hemoglobin content by an unknown mechanism [Lew VL, et al. (1995) Blood 86:334-341; Waugh RE, et al. (1992) Blood 79:1351-1358]; after similar to 120 d, responding to an unknown trigger, they are removed. We used theory from statistical physics and data from the hospital clinical laboratory [d'Onofrio G, et al. (1995) Blood 85:818-823] to develop a master equation model for RBC maturation and clearance. The model accurately identifies patients with anemia and distinguishes thalassemia-trait anemia from iron-deficiency anemia. Strikingly, it also identifies many pre-anemic patients several weeks before anemia becomes clinically detectable. More generally we illustrate how clinical laboratory data can be used to develop and to test a dynamic model of human pathophysiology with potential clinical utility.