Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS
Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS
复制标题
肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)的解体：ME/CFS患者microRNA表达谱的性别特异性变化
DOI：
10.1111/jcmm.15260
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发表时间：
2020-04-14
影响因子：
5.3
通讯作者：
Nathanson, Lubov
中科院分区：
文献类型：
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作者：
Cheema, Amanpreet K.;Sarria, Leonor;Nathanson, Lubov
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种多系统疾病，其特征是医学上无法解释的衰弱性疲劳，并提示免疫状态改变。我们的研究旨在探讨运动挑战下ME/CFS受试者外周血单个核细胞（PBMCs）的microRNAs （miRNAs）表达。这些发现强调了免疫反应和炎症与ME/CFS中差异miRNA表达的联系。本研究首次揭示了运动对ME/CFS男性和女性患者miRNA表达模式的影响，这一点尤为重要。这为理解不同miRNA表达模式和ME/CFS的运动后不适提供了新的证据。我们还报道了与ME/CFS患者营养状况相关的miRNA表达模式差异，强调了受试者代谢状态对分子变化的影响，在NINDS/CDC ME/CFS公共数据元素的临床研究中需要考虑。基于性别的mirna的鉴定为性别特异性ME/CFS易感性提供了重要的新见解，并要求探索适合性别的ME/CFS治疗方法。
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. The present study is particularly important in being the first to uncover the differences that exist in miRNA expression patterns in males and females with ME/CFS in response to exercise. This provides new evidence for the understanding of differential miRNA expression patterns and post-exertional malaise in ME/CFS. We also report miRNA expression pattern differences associating with the nutritional status in individuals with ME/CFS, highlighting the effect of subjects' metabolic state on molecular changes to be considered in clinical research within the NINDS/CDC ME/CFS Common Data Elements. The identification of gender-based miRNAs importantly provides new insights into gender-specific ME/CFS susceptibility and demands exploration of sex-suited ME/CFS therapeutics.