Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson's disease.
Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson's disease.
复制标题
DOI：
10.1002/mds.26128
复制
发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Grabowski TJ
中科院分区：
文献类型：
--
作者：
Madhyastha TM;Askren MK;Boord P;Zhang J;Leverenz JB;Grabowski TJ
PD 的皮质功能障碍可能是由于上行系统或内在皮质神经病理学的破坏引起的。我们引入并进行了代谢和萎缩的联合分析，能够确定在不伴有皮质萎缩的轻度帕金森病中是否发生代谢破坏。确定轻度帕金森病 (PD) 皮质受累的程度和空间模式。观察性的。 23 名患有轻度 PD 的认知正常参与者（平均 Hoehn & Yahr 2 期）和 21 名健康对照者 (HC) 分别对皮质厚度（通过 FreeSurfer 的结构 MRI 分析获得）和脑灌注测量值（通过 ASL 获得）进行独立分析，然后进行联合多因子分析，以确定灌注和皮质厚度的空间模式。我们确定了灌注和皮质厚度变化的模式，其特征是对称顶叶皮质变薄和楔前叶灌注减少，而前扣带皮层（ACC）、右前额回和内侧额回的厚度和灌注相对保留。这种模式的表达与运动系统症状和处理速度相关。在我们的非痴呆 PD 样本中，出现了关节顶叶皮质变薄和灌注不成比例减少的空间模式。我们没有发现在没有皮质变薄的情况下与灌注减少相关的 PD 相关成分。这表明帕金森病会影响皮质本身，即使症状相对轻微。
Cortical dysfunction in PD may be caused by disruption to ascending systems or intrinsic cortical neuropathology. We introduce and conduct a joint analysis of metabolism and atrophy capable of identifying whether metabolic disruption occurs in mild PD without cortical atrophy. To determine the extent and spatial pattern of cortical involvement in mild Parkinson Disease (PD). Observational. Twenty-three cognitively normal participants with mild PD (mean Hoehn & Yahr stage 2) and 21 healthy controls (HC) Cortical thickness (obtained from analysis of structural MRI with FreeSurfer) and cerebral perfusion measures (obtained from ASL) analyzed independently and then together in a joint multiple factorial analysis to identify spatial patterns of perfusion and cortical thickness. We identify a pattern of changes in perfusion and cortical thickness characterized by symmetric parietal cortical thinning and reduced precuneus perfusion, with relative preservation of thickness and perfusion in the anterior cingulate cortex (ACC), right prefrontal gyrus, and medial frontal gyrus. The expression of this pattern is correlated with motor system symptoms and speed of processing. A spatial pattern of joint parietal cortical thinning and disproportionate reduction in perfusion occurs in our nondemented PD sample. We found no PD-related components of reduced perfusion without cortical thinning. This suggests that PD affects the cortex itself, even when symptoms are relatively mild.