PARITY AND CANCER RISK IN SLOVAKIA
PARITY AND CANCER RISK IN SLOVAKIA
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DOI：
10.1002/ijc.2910360502
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发表时间：
1985-01-01
影响因子：
6.4
通讯作者：
SOMOGYI, J
中科院分区：
文献类型：
--
作者：
PLESKO, I;PRESTONMARTIN, S;SOMOGYI, J
使用 1968 年至 1977 年间在斯洛伐克和捷克斯洛伐克死亡的 45-74 岁女性的死亡率数据来检验胎次（活产儿数量）的影响或死于 20 种常见癌症的风险。在控制了年龄和死亡年份的影响后，对于胃癌、肝癌、胆囊癌、乳腺癌、宫颈癌和卵巢癌，胎次对风险的影响具有统计学意义，p < 0.001。子宫体和大脑的 p < 0.01 水平。产次对结肠癌或直肠癌没有影响。在经产妇女中，乳腺癌、子宫体癌、卵巢癌和脑癌的风险与产次水平相关的趋势显着，p < 0.001。胃癌的 p < 0.01 水平。有关乳腺癌和生殖器官癌症的均等性的研究结果与之前的报告一致。产次与消化道癌症的关联值得进一步研究。
Mortality data from women aged 45-74 who died between 1968 and 1977 in Slovakia, Czechoslovakia, were used to examine the effect of parity (number of live-born children) or risk of dying from each of 20 common cancers. After controlling for the effects of age and year of death, the effect of parity on risk was statistically significant at the p < 0.001 level, for cancers of the stomach, liver, gall-bladder, breast, cervix, and ovary; and at the p < 0.01 level for uterine corpus and brain. No effect of parity was seen for cancer of the colon or rectum. Among parous women the trend relating risk to level of parity was significant at the p < 0.001 level for cancers of the breast, uterine corpus, ovary and brain; and at the p < 0.01 level for stomach cancer. The findings relating parity to cancers of the breast and reproductive organs are consistent with previous reports. The associations of parity with cancers of the digestive tract deserve further study.